Afuco™ Anti-Human AOC3 ADCC Recombinant Antibody (BTT-1023), ADCC Enhanced (CAT#: AFC-043CL)
Anti-AOC3 ADCC Enhanced Antibody (BTT-1023) is an ADCC enhanced antibody produced by our Afuco™ platform. BTT1023 is a fully human monoclonal antibody targeting VAP-1 (vascular adhesion protein-1). VAP-1 is a completely new therapeutic target. The safety and efficacy of BTT1023 has earlier been investigated in small clinical trials in rheumatoid arthritis and psoriasis patients. In March 2015, BTT1023 transitioned into Phase 2 development in fibrotic conditions and received Orphan Drug Designation in the EU for the treatment of primary sclerosing cholangitis.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to cytosol & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/980/if_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to cytosol & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/980/if_selected.jpg
Figure 2 Lung
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/980/2500_A_1_4_val_selected.jpg
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/980/2500_A_1_4_val_selected.jpg
Figure 3 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/980/2500_A_7_3.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/980/2500_A_7_3.jpg
Figure 4 Soft tissue
(Fibroblasts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25797/57908_B_2_8.jpg
(Fibroblasts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25797/57908_B_2_8.jpg
Figure 5 RNA cell line category: Cell line enriched (ASC diff)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000131471-AOC3
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000131471-AOC3
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Primary Sclerosing Cholangitis; Psoriasis; Rheumatoid Arthritis
Product Property
- Purity
- >97%, by SDS-PAGE under reducing conditions
- Storage
- Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Target
- Alternative Names
- AOC3; amine oxidase, copper containing 3; HPAO; SSAO; VAP1; VAP-1; membrane primary amine oxidase; copper amine oxidase; placenta copper monamine oxidase; semicarbazide-sensitive amine oxidase; amine oxidase, copper containing 3 (vascular adhesion protein 1)
- Gene ID
- 8639
- UniProt ID
- Q16853
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-261 | Anti-Human AOC3 Recombinant Antibody (Vapaliximab) | WB, FC, IP, ELISA, Neut, FuncS, IF | IgG2 |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-137 | Anti-Human AOC3 Recombinant Antibody (Vepalimomab) | Neut, ELISA, IF, IP, FuncS, FC, ICC | IgM |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-045CL | Human Anti-AOC3 Recombinant Antibody (TAB-045CL) | ELISA | Human IgG |
| TAB-455CQ | Anti-Human AOC3 Recombinant Antibody (Timolumab) | ELISA, IHC, FC, IP, IF, FuncS | IgG4, κ |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0189 | Hi-Affi™ Rabbit Anti-AOC3 Recombinant Antibody (clone DS189AB) | IP, IHC-P, WB | Rabbit IgG |
Neuroscience Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-098CN | Human Anti-AOC3 Recombinant Antibody (clone Mo2D10) | ELISA, FC, IF, IHC, Inhib, FuncS | Human IgG1, κ |
| NS-099CN | Human Anti-AOC3 Recombinant Antibody (clone BTT-1002) | ELISA, FC, IF, IHC, Inhib, FuncS | Human IgG |
| NS-098CN-F(E) | Human Anti-AOC3 Recombinant Antibody (clone Mo2D10); Fab Fragment | ELISA, FC, IF, IHC | Human Fab |
| NS-099CN-F(E) | Human Anti-AOC3 Recombinant Antibody (clone BTT-1002); Fab Fragment | ELISA, FC, IF, IHC | Human Fab |
| NS-098CN-S(P) | Mouse Anti-AOC3 Recombinant Antibody (clone Mo2D10); scFv Fragment | ELISA, FC, IF, IHC | Mouse scFv |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1627LY-S(P) | Mouse Anti-AOC3 Recombinant Antibody (clone 1G3); scfv Fragment | ELISA | Mouse scfv |
| HPAB-1628LY-S(P) | Mouse Anti-AOC3 Recombinant Antibody (clone 3F10); scfv Fragment | ELISA | Mouse scfv |
| HPAB-1629LY-S(P) | Mouse Anti-AOC3 Recombinant Antibody (clone 3G6); scfv Fragment | ELISA | Mouse scfv |
| HPAB-0966-FY-F(E) | Human Anti-AOC3 Recombinant Antibody; Fab Fragment (HPAB-0966-FY-F(E)) | IF | Human Fab |
| HPAB-0967-FY-F(E) | Human Anti-AOC3 Recombinant Antibody; Fab Fragment (HPAB-0967-FY-F(E)) | IF | Human Fab |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1627LY-F(E) | Mouse Anti-AOC3 Recombinant Antibody (clone 1G3); Fab Fragment | ELISA | Mouse Fab |
| HPAB-1628LY-F(E) | Mouse Anti-AOC3 Recombinant Antibody (clone 3F10); Fab Fragment | ELISA | Mouse Fab |
| HPAB-1629LY-F(E) | Mouse Anti-AOC3 Recombinant Antibody (clone 3G6); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0966-FY-S(P) | Human Anti-AOC3 Recombinant Antibody; scFv Fragment (HPAB-0966-FY-S(P)) | IF | Human scFv |
| HPAB-0967-FY-S(P) | Human Anti-AOC3 Recombinant Antibody; scFv Fragment (HPAB-0967-FY-S(P)) | IF | Human scFv |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-261 | Afuco™ Anti-AOC3 ADCC Recombinant Antibody (Vapaliximab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS | ADCC enhanced antibody |
| AFC-TAB-455CQ | Afuco™ Anti-AOC3 ADCC Recombinant Antibody (Timolumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| AFC-TAB-137 | Afuco™ Anti-AOC3 ADCC Recombinant Antibody (Vepalimomab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0966-FY | Human Anti-AOC3 Recombinant Antibody (HPAB-0966-FY) | IF | Human IgG |
| HPAB-0967-FY | Human Anti-AOC3 Recombinant Antibody (HPAB-0967-FY) | IF | Human IgG |
| HPAB-0968-FY | Human Anti-AOC3 Recombinant Antibody (HPAB-0968-FY) | IF | Human IgG |
| HPAB-0969-FY | Human Anti-AOC3 Recombinant Antibody (HPAB-0969-FY) | IF | Human IgG |
| FAMAB-1004CQ | Mouse Anti-AOC3 Recombinant Antibody (clone 2D10) | IP, WB, ELISA, FC, IHC | Mouse IgG1 |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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