Afuco™ Anti-Human AOC3 ADCC Recombinant Antibody (BTT-1023), ADCC Enhanced
CAT#: AFC-043CL
Anti-AOC3 ADCC Enhanced Antibody (BTT-1023) is an ADCC enhanced antibody produced by our Afuco™ platform. BTT1023 is a fully human monoclonal antibody targeting VAP-1 (vascular adhesion protein-1). VAP-1 is a completely new therapeutic target. The safety and efficacy of BTT1023 has earlier been investigated in small clinical trials in rheumatoid arthritis and psoriasis patients. In March 2015, BTT1023 transitioned into Phase 2 development in fibrotic conditions and received Orphan Drug Designation in the EU for the treatment of primary sclerosing cholangitis.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to cytosol & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/980/if_selected.jpg
Normal Tissue
Figure 2 Lung
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/980/2500_A_1_4_val_selected.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/980/2500_A_7_3.jpg
Normal Tissue
Figure 4 Soft tissue
Fibroblasts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25797/57908_B_2_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (ASC diff)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000131471-AOC3
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Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Primary Sclerosing Cholangitis; Psoriasis; Rheumatoid Arthritis
Product Property
- Purity
- >97%, by SDS-PAGE under reducing conditions
- Storage
- Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Target
- Alternative Names
- AOC3; amine oxidase, copper containing 3; HPAO; SSAO; VAP1; VAP-1; membrane primary amine oxidase; copper amine oxidase; placenta copper monamine oxidase; semicarbazide-sensitive amine oxidase; amine oxidase, copper containing 3 (vascular adhesion protein 1)
- Gene ID
- 8639
- UniProt ID
- Q16853
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "AOC3"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-261 | Anti-Human AOC3 Recombinant Antibody (Vapaliximab) | WB, FC, IP, ELISA, Neut, FuncS, IF | IgG2 |
| CAT | Product Name | Application | Type |
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| TAB-137 | Anti-Human AOC3 Recombinant Antibody (TAB-137) | Neut, ELISA, IF, IP, FuncS, FC, ICC | IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-045CL | Human Anti-AOC3 Recombinant Antibody (TAB-045CL) | ELISA | Human IgG |
| TAB-455CQ | Anti-Human AOC3 Recombinant Antibody (Timolumab) | ELISA, IHC, FC, IP, IF, FuncS | IgG4, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0189 | Hi-Affi™ Rabbit Anti-AOC3 Recombinant Antibody (clone DS189AB) | IP, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-098CN | Human Anti-AOC3 Recombinant Antibody (clone Mo2D10) | ELISA, FC, IF, IHC, Inhib, FuncS | Human IgG1, κ |
| NS-099CN | Human Anti-AOC3 Recombinant Antibody (clone BTT-1002) | ELISA, FC, IF, IHC, Inhib, FuncS | Human IgG |
| NS-098CN-F(E) | Human Anti-AOC3 Recombinant Antibody (clone Mo2D10); Fab Fragment | ELISA, FC, IF, IHC | Human Fab |
| NS-099CN-F(E) | Human Anti-AOC3 Recombinant Antibody (clone BTT-1002); Fab Fragment | ELISA, FC, IF, IHC | Human Fab |
| NS-098CN-S(P) | Mouse Anti-AOC3 Recombinant Antibody (clone Mo2D10); scFv Fragment | ELISA, FC, IF, IHC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1627LY-S(P) | Mouse Anti-AOC3 Recombinant Antibody (clone 1G3); scfv Fragment | ELISA | Mouse scfv |
| HPAB-1628LY-S(P) | Mouse Anti-AOC3 Recombinant Antibody (clone 3F10); scfv Fragment | ELISA | Mouse scfv |
| HPAB-0967-FY-F(E) | Human Anti-AOC3 Recombinant Antibody; Fab Fragment (HPAB-0967-FY-F(E)) | IF | Human Fab |
| HPAB-0968-FY-F(E) | Human Anti-AOC3 Recombinant Antibody; Fab Fragment (HPAB-0968-FY-F(E)) | IF | Human Fab |
| HPAB-0969-FY-F(E) | Human Anti-AOC3 Recombinant Antibody; Fab Fragment (HPAB-0969-FY-F(E)) | IF | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1627LY | Mouse Anti-AOC3 Recombinant Antibody (clone 1G3) | ELISA | Mouse IgG |
| HPAB-1628LY | Mouse Anti-AOC3 Recombinant Antibody (clone 3F10) | ELISA | Mouse IgG |
| HPAB-1629LY | Mouse Anti-AOC3 Recombinant Antibody (clone 3G6) | ELISA | Mouse IgG |
| FAMAB-1004CQ | Mouse Anti-AOC3 Recombinant Antibody (clone 2D10) | IP, WB, ELISA, FC, IHC | Mouse IgG1 |
| FAMAB-1005CQ | Mouse Anti-AOC3 Recombinant Antibody (clone TK8-14) | IF, WB, FC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1627LY-F(E) | Mouse Anti-AOC3 Recombinant Antibody (clone 1G3); Fab Fragment | ELISA | Mouse Fab |
| HPAB-1628LY-F(E) | Mouse Anti-AOC3 Recombinant Antibody (clone 3F10); Fab Fragment | ELISA | Mouse Fab |
| HPAB-1629LY-F(E) | Mouse Anti-AOC3 Recombinant Antibody (clone 3G6); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0966-FY-S(P) | Human Anti-AOC3 Recombinant Antibody; scFv Fragment (HPAB-0966-FY-S(P)) | IF | Human scFv |
| HPAB-0967-FY-S(P) | Human Anti-AOC3 Recombinant Antibody; scFv Fragment (HPAB-0967-FY-S(P)) | IF | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-261 | Afuco™ Anti-AOC3 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-261) | FC, IP, ELISA, Neut, FuncS | ADCC enhanced antibody |
| AFC-TAB-455CQ | Afuco™ Anti-AOC3 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-455CQ) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| AFC-TAB-137 | Afuco™ Anti-AOC3 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-137) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY15 | AbPlus™ Anti-AOC3 Magnetic Beads (2D10) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY65 | Human Anti-AOC3 (clone Timolumab) scFv-Fc Chimera | ELISA | Human IgG4, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY422 | Anti-AOC3 Immunohistochemistry Kit | IHC | |
| VS-0525-XY423 | Anti-Mouse AOC3 Immunohistochemistry Kit | IHC |
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