Anti-APOA2 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


Creative Biolabs provides you with high-quality and reliable anti-Apolipoprotein A2 (APOA2) recombinant antibodies (rAbs). As the second most abundant structural protein of the high-density lipoprotein (HDL) particle, APOA2 is involved in the complex regulation of lipid metabolism and cardiovascular disease risk. We have developed robust anti-APOA2 antibodies for accurate quantification and functional study of this protein in health and disease.

APOA2: A Key Structural Component of HDL with Complex Metabolic Roles

APOA2 is a highly abundant apolipoprotein that makes up the second most prevalent protein component of HDL particles. Its presence in HDL confers the characteristic discoid shape to the particle and is essential for maintaining the structural integrity of HDL. However, the exact function of APOA2 remains a matter of debate and is seemingly context-dependent. While APOA2 exhibits relatively weak affinity to HDL, it modulates the enzymatic activities of HDL-associated proteins, such as LCAT and LPL. Genetic variants of APOA2 are associated with obesity, insulin resistance, and atherosclerosis, and APOA2 has been a target of interest for the study of cardiometabolic disease risk.

Alternative Names

apoAII; Apo-AII; ApoA-II

Background

This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia.

Protein class

Cancer-related genes, Candidate cardiovascular disease genes, Metabolic proteins, Plasma proteins

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enriched (Hepatocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enriched (Hep G2)

Interaction

Monomer. Homodimer; disulfide-linked. Also forms a disulfide-linked heterodimer with APOD (PubMed:7918467). Interacts with NAXE and NDRG1. (Microbial infection) Interacts with HCV core protein.

More Types Infomation

Anti-APOA2 rAb Products

Creative Biolabs recombinant anti-APOA2 antibodies are engineered for high performance. They are optimized for specificity and affinity for the target and do not exhibit cross-reactivity with other apolipoproteins. These high-affinity rAbs can be used to quantify APOA2 in plasma and other biological samples with high sensitivity, specificity, and reproducibility. Each lot of our anti-APOA2 antibody is validated for different applications such as ELISA and Western Blot and consistently meets our strict quality control criteria.

Table 1. Featured anti-APOA2 recombinant antibody products at Creative Biolabs.

Cat. No. Product Name Target Species Host Species Applications
ZG-0546J Rabbit Anti-APOA2 Recombinant Antibody (clone 6H2) (CAT#: ZG-0546J) Human Rabbit IgG ELISA, FC
MOB-0664MZ Mouse Anti-APOA2 Recombinant Antibody (clone CBLS-117) (CAT#: MOB-0664MZ) Human Mouse IgG1 IHC-P
MOB-2909z Mouse Anti-APOA2 Recombinant Antibody (clone 6F7) (CAT#: MOB-2909z) Human Mouse IgG1 WB, ELISA, IHC

Creative Quality Control

Creative Biolabs' name is synonymous with quality. We have earned the trust of the scientific community by never compromising on the quality of our products. Our anti-APOA2 recombinant antibodies are produced in-house under the strictest quality management guidelines. Every lot of anti-APOA2 antibody is evaluated for binding kinetics, purity, and performance in relevant applications. You will always receive the best and most consistent reagent for your metabolic disease research from Creative Biolabs.

IHC analysis. (Creative Biolabs Original)Fig.1 IHC analysis of anti-APOA2 antibody
(Cat# ZG-0546J, Creative Biolabs).

FC analysis. (Creative Biolabs Original)Fig.2 FC analysis of anti-APOA2 antibody
(Cat# ZG-0546J, Creative Biolabs).

Customer Reviews

Excellent
Th***s
Rabbit Anti-APOA2 Recombinant Antibody (clone 6H2) (CAT#: ZG-0546J)
For Western blotting of HDL fractions, we were very impressed with this recombinant antibody. Signal was very clean and specific. No cross-reactivity to other apolipoproteins. A great tool!
28/Jun/2024

rAb Production

Creative Biolabs uses the latest technology for the production of high-quality recombinant antibodies. We use optimized mammalian expression systems to produce recombinant anti-APOA2 antibodies that are correctly folded and glycosylated. Appropriate post-translational modifications (glycosylation) are crucial for the binding of our anti-APOA2 antibodies to the native lipoprotein. We produce our rAbs to the highest standard for your most demanding applications.

Featured Anti-APOA2 Recombinant Antibody Production PlatformsMilligram-scale. (Creative Biolabs Original)
Fig.3 Milligram-scale anti-APOA2 recombinant antibody production.

Gram-scale. (Creative Biolabs Original)Fig.4 Gram-scale anti-APOA2 recombinant antibody production.

rAb Modalities

Creative Biolabs offers multiple anti-APOA2 recombinant antibody modalities for cardiovascular and metabolic research. We have developed custom solutions in different antibody formats for different applications, from matched antibody pairs for the development of sandwich ELISA kits to full-length IgGs for use in other immunoassays.

APOA2 antibody production and modalities. (Creative Biolabs Original)Fig.5 Full-length anti-APOA2 recombinant antibody production and modalities.

Enhance your cardiovascular and metabolic research with Creative Biolabs' validated and consistent anti-APOA2 recombinant antibodies. We provide you with antibodies that are specifically engineered for high specificity and affinity, meeting your exacting standards. Place your trusted research in our capable hands and contact our scientific team today.

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