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APOBEC3H
The encoded protein is a cytidine deaminase that has antiretroviral activity by generating lethal hypermutations in viral genomes. Polymorphisms and alternative splicing in this gene influence its antiretroviral activity and are associated with increased resistence to human immunodeficiency virus type 1 infection in certain populations. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009] Diseases associated with APOBEC3H include Plantar Wart and Human Immunodeficiency Virus Type 1. Among its related pathways are Gene Expression and Formation of the Editosome.
Protein class
Enzymes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (T-cells, monocytes, dendritic cells, Cytotrophoblasts, NK-cells, Hofbauer cells)
Immune cell specificity
Group enriched (gdT-cell, NK-cell, memory CD8 T-cell, memory CD4 T-cell, T-reg, MAIT T-cell, naive CD8 T-cell)
Cell line specificity
Cell line enhanced (Daudi, HDLM-2, Karpas-707, U-266/70)
Interaction
Interacts with AGO1, AGO2 and AGO3.
Molecular function
Hydrolase
More Types Infomation
- Human Anti-APOBEC3H Recombinant Antibody; scFv Fragment (HPAB-0004-LS-S(P)) (HPAB-0004-LS-S(P))
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- Derivation: Phage display
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FC, WB
- Human Anti-APOBEC3H Recombinant Antibody (HPAB-0004-LS) (HPAB-0004-LS)
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- Species Reactivity: Human
- Type: Human lgG1
- Application: IB, FuncS, ELISA, FC, WB
- Human Anti-APOBEC3H Recombinant Antibody; Fab Fragment (HPAB-0004-LS-F(E)) (HPAB-0004-LS-F(E))
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- Derivation: Phage display
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC, WB
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For Research Use Only. Not For Clinical Use.