Anti-AQP3 Products

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For Research Use Only. Not For Clinical Use.

Enhance your dermatological, oncological and metabolic disease research with our premium anti-Aquaporin 3 (AQP3) recombinant antibodies. AQP3 is an important water and glycerol transporter whose function is critical for skin moisturization and energy metabolism. Our high-performance recombinant antibodies (rAbs) are designed to help you study the role of AQP3 in skin conditions, tumor progression and metabolic syndrome. This may facilitate the identification of new targets for developing therapeutic interventions.

AQP3: A Key Aquaglyceroporin in Skin Health and Cancer

Aquaporin 3 (AQP3) is an aquaglyceroporin, a class of aquaporins that can transport both water and small neutral solutes such as glycerol and urea. It is widely expressed in the epidermis, where it plays an important role in maintaining skin hydration, elasticity, and barrier function. Glycerol transport mediated by AQP3 is essential for adipocyte lipid metabolism and energy supply in proliferating cells. In disease conditions, AQP3 dysregulation has been implicated in the development of dry skin and other skin disorders. In cancers such as skin, colon, and breast cancers, overexpression of AQP3 has been reported to enhance cell proliferation and migration.

Alternative Names

Aquaporin 3 (Gill Blood Group); Aquaporin 3 (GIL Blood Group); Aquaglyceroporin-3; AQP-3; Gill Blood Group; Aquaporin 3; Aquaporin-3; GIL;

Background

This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

Anti-AQP3 rAb Products

Our recombinant anti-AQP3 antibodies have been engineered to provide you with optimal specificity and performance. We validate each batch rigorously to ensure accurate detection of AQP3 in tissue sections and cell preparations without cross-reactivity with other aquaporins. Suitable for IHC and Western Blot, these rAbs offer clarity and specificity that you need to study this multifunctional transporter with confidence.

Table 1. Featured anti-AQP3 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs has an arsenal of state-of-the-art expression systems at our disposal to produce our highest quality anti-AQP3 recombinant antibodies. We use optimized mammalian cell platforms to ensure the antibodies recognize the native conformation of the AQP3 channel to provide you with a reagent that has high biological activity and specificity for your most demanding experiments.

Featured Anti-AQP3 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-AQP3 recombinant antibody production.

Fig.2 Gram-scale anti-AQP3 recombinant antibody production.

rAb Modalities

Creative Biolabs has a wide range of customizable modalities of anti-AQP3 antibodies to power up new discoveries in dermatology and oncology. We have standard IgGs for functional assays, and if you need to remove the Fc region for structural studies, we can make Fab fragments for you. No matter how challenging your research and development efforts are across the world, we are here to help you with a customized solution.

Fig.3 Full-length anti-AQP3 recombinant antibody production and modalities.

Explore the physiological and pathological roles of AQP3 with Creative Biolabs' recombinant antibodies. Our portfolio provides high specificity and consistent performance that your studies on this important transporter demand. Choose Creative Biolabs as your antibody partner for reliable reagents that can take your important research findings to new frontiers. Get in touch with our scientific team today.