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ARAP3
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- Recombinant Anti-Human ARAP3 Antibody (MOB-2910z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: WB, IHC, FuncS
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- Recombinant Anti-Human ARAP3 Antibody Fab Fragment (MOB-2910z-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: RIA, IF, FuncS
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- Recombinant Anti-Human ARAP3 Antibody scFv Fragment (MOB-2910z-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: FC, IP, FuncS
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For Research Use Only. Not For Clinical Use.
Background
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Horizontal cells, Adipocytes, Hepatic stellate cells, Endothelial cells, Microglial cells)
Immune cell specificity
Group enriched (eosinophil, neutrophil)
Cell line specificity
Cell line enhanced (EFO-21, HUVEC TERT2, TIME)
Interaction
Interacts (via SAM domain) with INPPL1/SHIP2.
Molecular function
GTPase activation
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