ARAP3

Formats

Anti-ARAP3 Recombinant Antibody Products

Recombinant Anti-Human ARAP3 Antibody (MOB-2910z)
- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: WB, IHC, FuncS
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Recombinant Anti-Human ARAP3 Antibody Fab Fragment (MOB-2910z-F(E))
- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: RIA, IF, FuncS
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Recombinant Anti-Human ARAP3 Antibody scFv Fragment (MOB-2910z-S(P))
- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: FC, IP, FuncS
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For Research Use Only. Not For Clinical Use.

Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin.

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Horizontal cells, Adipocytes, Hepatic stellate cells, Endothelial cells, Microglial cells)

Immune cell specificity

Group enriched (eosinophil, neutrophil)

Cell line specificity

Cell line enhanced (EFO-21, HUVEC TERT2, TIME)

Interaction

Interacts (via SAM domain) with INPPL1/SHIP2.

Molecular function

GTPase activation

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