Intracellular
Cell type enhanced (Distal enterocytes, Proximal enterocytes, Paneth cells, Gastric mucus-secreting cells, Extravillous trophoblasts, Intestinal goblet cells)
Not detected in immune cells
Cell line enhanced (CAPAN-2, MCF7, OE19, SK-BR-3)
Interacts with ELMO2, EPHA2, RAC1 and RHOG; mediates activation of RAC1 by EPHA2. Interacts with TAX1BP3 (via PDZ domain). May interact with CDC42; stimulated by HPV16 E6.
Guanine-nucleotide releasing factor
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For Research Use Only. Not For Clinical Use.