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ARHGEF6
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For Research Use Only. Not For Clinical Use.
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation.
Protein class
Cancer-related genes, Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (granulocytes, Granulosa cells, Microglial cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (HEL, HL-60, HMC-1, JURKAT, U-937)
Interaction
Interacts with PAK kinases through the SH3 domain. Interacts with GIT1. Component of cytoplasmic complexes, which also contain PXN, GIT1 and PAK1 (By similarity). Interacts with PARVB. Interacts with BIN2. Identified in a complex with BIN2 and GIT2.
Molecular function
Guanine-nucleotide releasing factor
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