Transcription factors
Intracellular
Cell type enhanced (Urothelial cells, Prostatic glandular cells, Pancreatic endocrine cells, Excitatory neurons, Basal prostatic cells)
Immune cell enhanced (basophil)
Cell line enhanced (HDLM-2, U-2197)
Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, ARNTL/BMAL1 or ARNTL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with CLOCK to form the ARNTL2/BMAL2-CLOCK transactivator. Can form heterodimers or homodimers which interact directly with CLOCK to form the transcription activator. Interacts with NPAS2 and HIF1A. Interacts with PER2 (By similarity).
Activator, DNA-binding
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For Research Use Only. Not For Clinical Use.