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ASAH2
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For Research Use Only. Not For Clinical Use.
Ceramidases (EC 3.5.1.23), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger (see MIM 603730).
Protein class
Enzymes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Proximal enterocytes, Late spermatids, Muller glia cells, Sertoli cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Low cell line specificity
Molecular function
Hydrolase
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