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ATG12
Anti-ATG12 Recombinant Antibody Products
- Mouse Anti-ATG12 Recombinant Antibody (clone 1-11) (MRO-0135-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgE
- Application: WB, IHC, IF
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- Rabbit Anti-ATG12 Polyclonal Antibody (MRO-1664-CN) (MRO-1664-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC
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- Rabbit Anti-ATG12 Polyclonal Antibody (MRO-1665-CN) (MRO-1665-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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For Research Use Only. Not For Clinical Use.
Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998 [PubMed 9852036]).
Protein class
Transporters
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Forms a conjugate with ATG5 (PubMed:11096062, PubMed:12207896, PubMed:11825910, PubMed:17709747, PubMed:26812546, PubMed:23202584). The ATG12-ATG5 conjugate forms a complex with several units of ATG16L1 (PubMed:23202584). Forms an 800-kDa complex composed of ATG12-ATG5 and ATG16L2 (By similarity). Interacts with DHX58/RIG-1, IFIH1/MDA5 and MAVS/IPS-1 in monomeric form as well as in ATG12-ATG5 conjugate. The interaction with MAVS is further enhanced upon vesicular stomatitis virus (VSV) infection (PubMed:17709747). Interacts with ATG3 and ATG7 (PubMed:11096062, PubMed:12207896, PubMed:11825910, PubMed:23202584). Interacts with ATG10 (By similarity). Interacts with TECPR1 (PubMed:22342342).
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