Anti-ATOX1 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is your go-to source for metallobiology and cancer research with highly specific anti-ATOX1 recombinant antibodies. As the major chaperone responsible for transporting copper to the secretory pathway, ATOX1 plays a crucial role in regulating copper homeostasis and is a protein of interest in cancer. Our top-quality antibodies provide you with the necessary tools for studying copper trafficking, angiogenesis, and cancer cell proliferation.

ATOX1: The Copper Chaperone for the Secretory Pathway

Antioxidant Protein 1 (ATOX1) is a small cytosolic copper chaperone that is responsible for binding copper ions from the C-terminus of the Ctr1 copper importer at the plasma membrane and shuttling the copper through the cytosol to the trans-Golgi Network (TGN), where it is released to the copper-transporting ATPases ATP7A and ATP7B for loading into copper-dependent enzymes (i.e., those involved in collagen cross-linking, pigmentation, etc.). ATOX1 also has a nuclear localization signal and can act as a transcription factor, and its overexpression in cancer has been associated with increased proliferation and angiogenesis.

Alternative Names

ATOX1; ATX1; HAH1; Copper Transport Protein ATOX1; ATX1 Antioxidant Protein 1 Homolog; Antioxidant 1 Copper Chaperone; ATX1 (Antioxidant Protein 1, Yeast) Homolog 1; ATX1 Antioxidant Protein 1 Homolog (Yeast); Metal Transport Protein ATX1

Background

This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome.

Anti-ATOX1 rAb Products

Creative Biolabs’ anti-ATOX1 recombinant antibodies are specifically engineered to deliver superior specificity. The antibodies are thoroughly validated to ensure they specifically and accurately detect ATOX1 protein. Optimized for Western Blot to analyze expression and immunofluorescence to visualize cellular localization, our recombinant antibodies are the reliable partners you need for your cell biology research.

Table 1. Featured anti-ATOX1 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs has developed and invested in advanced antibody production platforms to serve the growing needs of the metallobiology community. Our anti-ATOX1 recombinant antibodies are expressed in optimized systems for accurate recognition of this small chaperone, resulting in a specific and active antibody for your applications.

Featured Anti-ATOX1 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-ATOX1 recombinant antibody production.

Fig.2 Gram-scale anti-ATOX1 recombinant antibody production.

rAb Modalities

Creative Biolabs is passionate about enabling the world’s scientists to do their best work by providing flexible antibody solutions. Our anti-ATOX1 recombinant antibodies can be produced in a variety of customizable modalities to address a wide range of experimental needs.

Fig.3 Full-length anti-ATOX1 recombinant antibody production and modalities.

Take the next step in dissecting the intricacies of copper homeostasis with Creative Biolabs’ highly specific anti-ATOX1 recombinant antibodies. Our validated and consistent products are designed to provide you with a reliable research tool to explore this key protein. Put your trust in our expertise and equip your research with the best. Reach out to our scientific team today.