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AURKB
Loading...Anti-AURKB Products
- Mouse Anti-AURKB Recombinant Antibody (clone 13E8D3) (MOB-0870MZ)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA
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- Rabbit Anti-AURKB Recombinant Antibody (clone CBACN-056) (MRO-0146-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IHC, IP
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- Sheep Anti-AURKB Antibody (VS-0722-YJ010) (VS1-YJ10)
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- Species Reactivity: Human
- Type: Sheep IgG
- Application: WB, IHC-P
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- Rabbit Anti-AURKB Recombinant Antibody (VS3-WK1104) (VS3-WK1104)
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- Derivation: Rabbit
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC, IP
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- Anti-Mouse AURKB Immunohistochemistry Kit (VS-0525-XY661)
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- Species Reactivity: Human, Mouse, Rat, Bovine
- Target: AURKB
- Application: IHC
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- Anti-AURKB Immunohistochemistry Kit (VS-0525-XY660)
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- Species Reactivity: Human
- Target: AURKB
- Application: IHC
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- Rabbit Anti-AURKB Recombinant Antibody (clone AFY0052) (MOR-0081-FY)
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: ICC, IHC-P, WB
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding different isoforms have been found for this gene.
Protein class
Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Extravillous trophoblasts, Erythroid cells, Cytotrophoblasts, Hofbauer cells, Granulosa cells)
Immune cell specificity
Immune cell enhanced (T-reg)
Cell line specificity
Low cell line specificity
Interaction
Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; predominantly independent AURKB- and AURKC-containing complexes exist (PubMed:11516652, PubMed:12925766, PubMed:14722118, PubMed:15249581, PubMed:18591255, PubMed:27332895, PubMed:20562864). Associates with RACGAP1 during M phase (PubMed:12689593). Interacts with CDCA1, EVI5, JTB, NDC80, PSMA3, SEPTIN1, SIRT2 and TACC1 (PubMed:14602875, PubMed:14674694, PubMed:15064709, PubMed:16179162, PubMed:16764853, PubMed:17726514, PubMed:21225229). Interacts with SPDYC; this interaction may be required for proper localization of active, Thr-232-phosphorylated AURKB form during prometaphase and metaphase (PubMed:20605920). Interacts with p53/TP53 (PubMed:20959462). Interacts (via the middle kinase domain) with NOC2L (via the N- and C-terminus domains) (PubMed:20959462). Interacts with TTC28 (PubMed:23036704). Interacts with RNF2/RING1B (By similarity).
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase
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