Anti-AURKB Recombinant Antibody Products

Loading...

Anti-AURKB Products

Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

For Research Use Only. Not For Clinical Use.

Creative Biolabs is a leading supplier of research tools for cancer and cell cycle researchers. We are committed to developing and providing the highest quality anti-Aurora Kinase B (AURKB) recombinant antibodies. AURKB is the catalytic subunit of the chromosomal passenger complex (CPC) that serves as the key regulator of chromosome segregation and cytokinesis. Creative Biolabs' anti-AURKB recombinant antibodies are a critical tool for understanding mitosis and the development of new anti-cancer therapeutics targeting this important kinase family for its role in ensuring genomic stability during cell division.

AURKB: The Guardian of Chromosome Segregation

AURKB, like AURKA, is a serine/threonine kinase. As the catalytic core of the Chromosomal Passenger Complex (CPC), it is a key player in mitosis regulation. The CPC is first found at the centromeres during early mitosis before relocating to the spindle midzone in anaphase. The key function of AURKB is to help microtubules attach correctly to the kinetochore; it is able to sense when microtubules are not attached in the correct manner and destabilize them until the errors are corrected. It also plays an important role in the spindle assembly checkpoint and in the completion of cytokinesis. AURKB is, like AURKA, often overexpressed in cancer and is a key target for the development of anti-mitotic anti-cancer drugs.

Alternative Names

AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM-1; ARK-2; STK-1; STK12; PPP1R48; aurkb-sv1; aurkb-sv2; aurora kinase B; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora- and Ipl1-like midbody-associated protein 1; aurora-1; aurora-B; aurora-related kinase 2; aurora/IPL1-related kinase 2; protein phosphatase 1, regulatory subunit 48; serine/threonine kinase 12; serine/threonine-protein kinase 12; serine/threonine-protein kinase 5; serine/threonine-protein kinase aurora-B

Background

This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding different isoforms have been found for this gene.

Anti-AURKB rAb Products

Creative Biolabs' anti-AURKB recombinant antibodies have been developed and optimized to target the AURKB enzyme specifically and are carefully validated to not cross-react with AURKA or AURKC. It is important to note the isoform specificity of these antibodies for your research, as this could drastically change the function and target recruitment of the kinase family. Our anti-AURKB rAbs have been optimized for immunofluorescence, allowing for tracking of its dynamic localization, as well as for Western Blot, to give you a clear, reliable readout for your cell cycle studies.

Table 1. Featured anti-AURKB recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs is driven by a commitment to quality unmatched in the industry. This commitment to quality defines our work in the production of our anti-AURKB recombinant antibodies as we use a strict quality assurance program to ensure we are delivering the best possible reagents. Quality is built into every step of the development process and each lot of antibodies is fully validated for purity, isoform specificity, and performance in the indicated applications to provide you with a high-integrity reagent that will generate clear and reliable data.

Customer Reviews

Excellent

Na***n
Rabbit Anti-AURKB Recombinant Antibody (clone 4E5)

The anti-AURKB antibody from Creative Biolabs was great for our immunofluorescence studies. It stained beautifully on the centromeres and then later on the midbody as the CPC moves with the chromatids, really making it easy to track this complex during mitosis.

13/Jan/2023

Excellent

Ju***n
Mouse Anti-AURKB Recombinant Antibody (ZG-0312F)

The isoform specificity of this antibody is excellent. It gave a very clean signal for AURKB in our lysates with no cross-reactivity or background from AURKA, which was crucial for our inhibitor studies.

24/Jun/2024

rAb Production

Creative Biolabs has harnessed the latest antibody production technologies in order to support your cutting-edge oncology research. Our anti-AURKB recombinant antibodies are expressed in systems optimized to produce antibodies that are able to accurately recognize the native kinase in its complex and as such provide a research tool with the utmost specificity and activity.

Featured Anti-AURKB Recombinant Antibody Production Platforms
Fig.3 Milligram-scale anti-AURKB recombinant antibody production.

Fig.4 Gram-scale anti-AURKB recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to developing and providing a full range of customizable and flexible reagents to address the needs of cell biology research. Our anti-AURKB recombinant antibodies are no exception and are available in a range of modalities including phospho-specific versions of the antibody. These tools give researchers around the world the ability to study this key gatekeeper of chromosome segregation and stability.

Fig.5 Full-length anti-AURKB recombinant antibody production and modalities.

Creative Biolabs' anti-AURKB recombinant antibodies give you the tools to unravel the complex regulation of mitosis with the ultimate in antibody validation and performance. Our products are developed to the highest standards with end-use validation as the central part of our process. Choose Creative Biolabs for reliable and high-performing antibodies for your research into cancer and genomic stability. Our team of specialists is on hand to help you select the right product for your studies and answer your questions. Contact them today to accelerate your next discovery.