Anti-AURKC Products

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For Research Use Only. Not For Clinical Use.

Support research into reproductive biology and oncology with Creative Biolabs' highly specific recombinant antibodies (rAbs) to Aurora Kinase C (AURKC). Although it shares homology with AURKA and AURKB, the expression of AURKC is more limited and is thought to be essential for meiosis. We offer high quality antibodies for research into spermatogenesis, oogenesis and the aberrant expression of AURKC in cancer.

AURKC: The Meiotic Aurora Kinase

AURKC is a serine/threonine kinase related to AURKA and AURKB both in structure and function. It is highly homologous to these other two aurora kinases but is very tightly regulated and is expressed almost exclusively in meiotic cells of the testis and ovary. Aurora Kinase C is a chromosomal passenger protein involved in both meiosis I and meiosis II, where it is likely to have overlapping function to AURKB in these germ cells to promote proper chromosome segregation. Genetic defects in AURKC result in the formation of large-headed multi-flagellated spermatozoa and male infertility. In some cancer types, AURKC is aberrantly re-expressed where it may contribute to aneuploidy.

Alternative Names

AURKC; aurora kinase C; AIE2; AIK3; ARK3; AurC; SPGF5; STK13; aurora-C; ARK-3; aurora 3; aurora-related kinase 3; aurora/IPL1/EG2 protein 2; aurora/IPL1-related kinase 3; serine/threonine-protein kinase 13; serine/threonine-protein kinase aurora-C; serine/threonine kinase 13 (aurora/IPL1-like);

Background

This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants.

Anti-AURKC rAb Products

Our anti-AURKC recombinant antibodies have been designed with exceptional specificity in mind. They have been carefully validated to recognize AURKC without cross-reactivity to the highly homologous AURKA and AURKB kinases. This is critical for the accurate study of its unique function. Our rAbs have been optimized for IHC on gonadal tissue and for Western Blot.

Table 1. Featured anti-AURKC recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs uses leading-edge production technologies to support your pioneering research into reproductive biology. Our anti-AURKC recombinant antibodies are expressed in an optimized system to help ensure it is accurately recognizing the native meiotic kinase so you get a highly specific and active reagent for your discovery research.

Featured Anti-AURKC Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-AURKC recombinant antibody production.

Fig.2 Gram-scale anti-AURKC recombinant antibody production.

rAb Modalities

Creative Biolabs is dedicated to supporting innovative research and discovery by providing flexible, cutting-edge antibody solutions. Our anti-AURKC recombinant antibodies are available in a range of customizable formats to help meet the needs of any experiment, helping researchers all over the world to better understand the unique role of this meiotic kinase in health and disease.

Fig.3 Full-length anti-AURKC recombinant antibody production and modalities.

Explore the unique role of Aurora Kinase C in meiosis and cancer with Creative Biolabs' highly specific recombinant antibodies. Our portfolio is designed with the isoform-specific precision and reliable performance you need to study this distinct kinase. Trust our quality to be the solid foundation for your discoveries. Get in touch with our expert team today.