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AURKC
This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants.
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Group enriched (Early spermatids, Spermatocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (NTERA-2)
Interaction
Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; predominantly independent AURKB- and AURKC-containing complexes exist; in the complex interacts directly with BIRC5/survivin and INCENP. Interacts with TACC1.
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
- Mouse Anti-AURKC Recombinant Antibody (clone 5G8) (MOB-0987CT)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB
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For Research Use Only. Not For Clinical Use.