Anti-ACY1 Products

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For Research Use Only. Not For Clinical Use.

Are you struggling with inconsistent antibody performance in amino acid metabolism studies or delayed therapeutic development for inborn errors? Creative Biolabs' anti-ACY1 recombinant antibodies combine advanced recombinant engineering and epitope-specific validation to deliver unmatched specificity for ACY1 detection. Designed for reproducibility across ELISAs, immunohistochemistry, and functional assays, these biologics empower researchers to streamline experimental workflows and accelerate drug discovery timelines.

ACY1: A Critical Enzyme in Amino Acid Metabolism

Aminoacylase-1 (ACY1), a zinc-binding hydrolase, plays a pivotal role in cytosolic protein degradation by cleaving N-acylated amino acids. Its dysfunction is linked to metabolic disorders, neurodevelopmental abnormalities, and cancer progression. Creative Biolabs' anti-ACY1 recombinant antibodies enable precise detection and functional characterization of this enzyme, supporting research into molecular diagnostics and therapeutic targeting.

Alternative Names

Aminoacylase-1; ACY-1; ACY1D; N-acyl-L-amino-acid amidohydrolase; EC 3.5.1.14.

Background

This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18. [provided by RefSeq, Nov 2010]

Anti-ACY1 rAb Products

Creative Biolabs' anti-ACY1 recombinant antibodies are engineered for high affinity and minimal cross-reactivity across human, mouse, and rat models. Available in murine, rat, and humanized formats, these antibodies are validated for ELISA, flow cytometry, and in vivo functional studies, ensuring reliability for preclinical and diagnostic applications.

Table.1 Representative anti-ACY1 recombinant antibody developed by Creative Biolabs.

Creative Quality Control

Creative Biolabs applies stringent quality control to all anti-ACY1 recombinant antibody products. Each lot is thoroughly validated for specificity, sensitivity, and functional activity. This rigorous process ensures that the antibodies consistently meet high-performance standards required for demanding experimental applications.

Customer Reviews

rAb Production

Utilizing cutting-edge mammalian expression systems, our production of anti-ACY1 recombinant antibodies ensures optimal post-translational modifications and robust biological activity. Our efficient and scalable manufacturing process follows stringent protocols, ensuring high yields and consistent quality across products. This sophisticated production platform allows us to deliver superior antibodies suitable for both research and prospective clinical applications.

Featured Anti-ACY1 Recombinant Antibody Production Platforms
Fig.5 Synthesis of ACY1-specific recombinant antibodies at milligram scale.

Fig.6 Gram-scale synthesis of recombinant antibodies specific to ACY1.

rAb Modalities

Creative Biolabs offers anti-ACY1 recombinant antibodies in diverse modalities, such as antibody fragments, bispecific antibodies, and other configurations, providing flexibility for a range of experimental designs.

Fig.7 Methods for synthesizing complete recombinant antibodies targeting ACY1.

With 20+ years of expertise in antibody engineering, Creative Biolabs is your trusted collaborator for ACY1-targeted research and therapeutic development. Our team provides customized solutions for assay optimization, epitope mapping, and large-scale production. Contact us today to discuss your project.