BAG1

Recombinant Antibody Products Formats

Anti-BAG1 Recombinant Antibody Products

Rabbit Anti-BAG1 Polyclonal Antibody (MRO-1678-CN) (MRO-1678-CN)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF
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Mouse Anti-Bag1 Recombinant Antibody (ZG-0325F) (ZG-0325F)
- Type: Mouse IgG
- Application: WB
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Mouse Anti-BAG1 Recombinant Antibody (clone 2C12-A8-1D7) (VS3-QX101)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB
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Mouse Anti-BAG1 Recombinant Antibody (clone F11-A7) (VS3-WK71)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA
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Recombinant Rabbit Anti-BAG1 Antibody (clone R07-8C1) (VS3-FY132)
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC-P, IP
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Mouse Anti-BAG1 Recombinant Antibody (clone CBLS-162) (MOB-0887MZ)
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: IF, WB
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Hi-Affi™ Rabbit Anti-BAG1 Recombinant Antibody (clone DS318AB) (MOR-0318)
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC, ICC, IP
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Mouse Anti-BAG1 Recombinant Antibody (clone 1E4B5) (VS7-HM202)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ICC, FCM
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Mouse Anti-BAG1 Recombinant Antibody (clone 2F7A11) (VS7-HM203)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: FCM
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For Research Use Only. Not For Clinical Use.

The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X.

Protein class

Cancer-related genes

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Late spermatids, Early spermatids)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (HeLa, NB-4)

Interaction

Homodimer. Forms a heteromeric complex with HSP70/HSC70 (PubMed:9305631). Binds to the ATPase domain of HSP/HSC70 chaperones. Isoform 1, isoform 3 and isoform 4 but not isoform 2 interact with HSPA8/HSC70 (PubMed:27474739, PubMed:24318877, PubMed:9305631, PubMed:9679980). Interacts with NR3C1 (PubMed:10477749). Interacts with the N-terminal region of STK19 (PubMed:15986447). Interacts with PPP1R15A (PubMed:12724406). Interacts with BCL2 in an ATP-dependent manner. Isoform 2 does not interact with BCL2 (PubMed:9305631). Interacts with SIAH1 (PubMed:9582267). Interacts with HSPA8 (via NBD) (PubMed:27474739, PubMed:24318877). Interacts with HSPA1A (via NBD) and HSPA1B (via NBD) (PubMed:24318877). Interacts with SIAH2 (By similarity).

Molecular function

Chaperone

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