Anti-BAG1 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs, a premier provider of anti-BAG1 recombinant antibodies, is at the forefront of scientific research into cell stress and cancer biology. BAG1 (BCL2 Associated Athanogene 1) is a multi-functional co-chaperone that regulates a range of proteins, including heat shock proteins and nuclear hormone receptors. By modulating the activity of these proteins, BAG1 is central to cellular protein quality control and survival. Our high-quality anti-BAG1 antibodies are designed to help you study these important pathways and reveal their roles in proteostasis, apoptosis, and cancer.

BAG1: A Co-Chaperone Linking Chaperones to the Proteasome

Cellular chaperones, like Hsp70, are key components of the protein quality control system that maintain cellular proteostasis and homeostasis. BAG1 is a co-chaperone that directly interacts with and regulates Hsp70 activity. Its main function is binding the ATPase domain of the Hsc70/Hsp70 chaperone and serving as a nucleotide exchange factor. In this way, BAG1 controls chaperone activity and its ability to fold client proteins. It also contains a ubiquitin-like domain, allowing it to link the chaperone complex directly to the proteasome and mediate the degradation of misfolded proteins. BAG1 also interacts with and potentiates the anti-apoptotic function of BCL2 and can modulate the activity of steroid hormone receptors.

Alternative Names

BAG-1; RAP46

Background

The BCL2 oncogene is a membrane protein that inhibits a step in a pathway leading to apoptosis (programmed cell death). The protein encoded by this gene binds to BCL2 and is therefore known as BCL2-associated athanogene. This gene product augments BCL2 anti-apoptotic function, and appears to function as a bridge between growth factor receptors and anti-apoptotic machinery. This mRNA encodes multiple protein isoforms by utilization of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been identified on the X chromosome.

Anti-BAG1 rAb Products

Creative Biolabs' anti-BAG1 recombinant antibodies are designed for high specificity and sensitivity to allow the reliable detection of BAG1 and its isoforms. Our anti-BAG1 rAbs are validated for common applications, such as co-immunoprecipitation to study its interaction with Hsp70 and Western Blot to measure its expression in response to cellular stress or in cancer cells.

Table 1. Featured anti-BAG1 recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs is dedicated to the highest standards of scientific rigor. Production of our anti-BAG1 recombinant antibodies is tightly controlled by a rigorous quality assurance program. Every lot is tested for purity, specificity, and consistent performance in validated applications. This ensures that you receive a high-quality reagent that can be relied upon to produce clean, reproducible results.

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rAb Production

Creative Biolabs' mission is to speed progress in critical areas of science such as protein quality control. We use the most advanced antibody production technologies to make our recombinant antibodies, including anti-BAG1. Our anti-BAG1 recombinant antibodies are expressed in optimized systems to produce antibodies that most closely recognize the native protein. This gives you the confidence that you will receive a product with high biological relevance and activity for your research.

Featured Anti-BAG1 Recombinant Antibody Production Platforms
Fig.2 Milligram-scale anti-BAG1 recombinant antibody production.

Fig.3 Gram-scale anti-BAG1 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to providing innovative and adaptable tools to empower the research community. Our anti-BAG1 recombinant antibodies are available in a range of customizable modalities to support your work in studying this critical regulator of cellular proteostasis.

Fig.4 Full-length anti-BAG1 recombinant antibody production and modalities.

Accelerate your research into chaperone networks and cell survival with Creative Biolabs' premium anti-BAG1 recombinant antibodies. From high specificity to rigorous application validation, our portfolio is designed to provide the tools you need for your research. Contact our specialists today to learn more.