+ Filter
Loading...
BCL2L10
Loading...Anti-BCL2L10 Products
- Mouse Anti-BCL2L10 Recombinant Antibody (clone 1B11) (MOB-0244CT)
-
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: ELISA, WB
Compare
View More Products
Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag
More Infomation
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
For Research Use Only. Not For Clinical Use.
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul 2008]
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Distal tubular cells, Proximal enterocytes, Proximal tubular cells, Suprabasal keratinocytes, Squamous epithelial cells)
Immune cell specificity
Immune cell enhanced (basophil)
Cell line specificity
Cell line enriched (NB-4)
Interaction
Interacts with BAX (PubMed:11278245, PubMed:23235460). Interacts with BCL2 and BCL2L1/BCLX (PubMed:11278245, PubMed:11593390). Interacts with APAF1 (By similarity). Interacts with ITPR1, ITPR2 and ITPR3; the interaction with ITPR1 is increased in the presence of AHCLY1 (PubMed:27995898). Interacts with AHCYL1 (PubMed:27995898). Interacts with HIP1R (via ENTH and I/LWEQ domains) (PubMed:19255499). Interacts with CASP9 (PubMed:19255499). Interacts with BCL2L11/BIM (PubMed:22498477, PubMed:23563182, PubMed:23235460). Interacts with BIK (PubMed:23563182, PubMed:23235460). Interacts with UBQLN4 (PubMed:34245648). Interacts with NME2/NM23-H2 (PubMed:17532299). Interacts with PMAIP1/NOXA (PubMed:23563182). Interacts with TPX2 (By similarity). Interacts with UBQLN1; in the cytoplasm (PubMed:22233804). Interacts (via BH1 domain) with BECN1 (PubMed:22498477).
More Types Infomation