Anti-BCL2L2 Products

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For Research Use Only. Not For Clinical Use.

Explore the mechanisms of apoptosis and cancer with high-fidelity anti-BCL2L2 (BCL-w) recombinant antibodies from Creative Biolabs. BCL-w is an important anti-apoptotic BCL2 family member implicated in cell survival in hematopoietic cells and specific cancers. Our quality antibodies are crucial to unravel its unique functions and therapeutic potential.

BCL2L2: An Anti-Apoptotic Protein with Roles in Hematopoiesis and Cancer

BCL2 Like 2 (BCL2L2), also known as BCL-w, is a pro-survival member of the BCL2 family of proteins. It is expressed on the outer mitochondrial membrane, similar to its close homologs BCL2 and BCL-xL. BCL-w exerts its anti-apoptotic effects by binding and sequestering pro-apoptotic BCL2 family members, including BAX, BAK, and BH3-only proteins. BCL-w is critical for hematopoietic cell survival and is required for normal spermatogenesis. It is also overexpressed in certain cancers, including gastric and colon cancer, where it promotes tumor cell survival and resistance to chemotherapy.

Alternative Names

BCLW; BCL-W; PPP1R51; BCL2-L-2

Background

The protein encoded by this gene is a member of the BCL-2 family of proteins. Hetero- or homodimers of these proteins function as regulators of apoptosis, with some members acting in anti-apoptotic and others in pro-apoptotic ways. Expression of this gene in cells has been shown to result in decreased cell apoptosis in cytotoxic conditions. Analysis of the related gene in the mouse suggests a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene showed an essential role in adult spermatogenesis. Alternative splicing results in the production of multiple transcript variants. Read-through transcription from this gene into the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene also occurs.

Anti-BCL2L2 rAb Products

Creative Biolabs' anti-BCL2L2 recombinant antibodies are designed for superior isoform specificity. Each lot is rigorously validated for its ability to detect the BCL-w protein without cross-reactivity to other BCL2 family members. This isoform-specific reactivity is critical for studying its distinct biological role. Optimized for Western Blot and IHC applications, our rAbs are tailored to provide clear, reliable results for your cell survival studies.

Table 1. Featured anti-BCL2L2 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs is committed to providing the most advanced reagents for oncology and cell biology research. Our anti-BCL2L2 recombinant antibodies are produced in state-of-the-art systems. They are expressed in optimized systems to ensure they precisely recognize the native protein, so you can rely on them to be specific and active.

Featured Anti-BCL2L2 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-BCL2L2 recombinant antibody production.

Fig.2 Gram-scale anti-BCL2L2 recombinant antibody production.

rAb Modalities

Innovative and versatile research solutions are a hallmark of Creative Biolabs. Our anti-BCL2L2 recombinant antibodies are available in a range of customizable modalities to meet your experimental needs. Empower researchers worldwide to study this critical survival protein with Creative Biolabs.

Fig.3 Full-length anti-BCL2L2 recombinant antibody production and modalities.

Decipher the unique functions of BCL-w in cell survival and cancer with high-fidelity anti-BCL2L2 recombinant antibodies from Creative Biolabs. Our portfolio stands out with our commitment to rigorous validation and outstanding performance. The ideal tools for your research are just a conversation away. Reach out to our experts today.