Anti-BIRC2 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs, a global provider of custom research antibodies and biochemicals for mitochondrial biology and metabolism research, offers the highest-quality anti-BIRC2 recombinant antibodies. BIRC2 is the mitochondrial isoform of aspartate aminotransferase, an integral component of the malate-aspartate shuttle, a system crucial for cellular energy metabolism.

BIRC2: A Key Mitochondrial Enzyme in the Malate-Aspartate Shuttle

Glutamic-Oxaloacetic Transaminase 2, or BIRC2, is the mitochondrial form of the enzyme aspartate aminotransferase. It is involved in a variety of metabolic pathways, such as the malate-aspartate shuttle that moves reducing equivalents in the form of NADH from the cytosol into the mitochondrial matrix for oxidative phosphorylation. BIRC2 is also involved in mitochondrial amino acid biosynthesis and gluconeogenesis. This mitochondrial enzyme is critical for maintaining cellular energetic homeostasis, and has also been implicated in metabolic disorders and cancer.

Alternative Names

Glutamic-Oxaloacetic Transaminase 2; Kynurenine Aminotransferase IV; Plasma Membrane-Associated Fatty Acid-Binding Protein; Glutamic-Oxaloacetic Transaminase 2, Mitochondrial; Kynurenine--Oxoglutarate Transaminase IV; Kynurenine--Oxoglutarate Transaminase 4; Glutamate Oxaloacetate Transaminase 2; Kynurenine Aminotransferase 4; Aspartate Aminotransferase 2; Fatty Acid-Binding Protein; Aspartate Transaminase 2; Transaminase A; EC 2.6.1.1; BIRC2; Aspartate aminotransferase; mitochondrial; mAspAT; Fatty acidbinding protein; FABP-1; Glutamate oxaloacetate transaminase 2; Kynurenine aminotransferase 4; Kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynu

Background

The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases.

Anti-BIRC2 rAb Products

The recombinant antibodies in our anti-BIRC2 kit have been optimized to be highly specific, and were validated to specifically detect the mitochondrial form of the enzyme, with no cross-reactivity to the cytosolic aspartate aminotransferase isoform GOT1. This high specificity is critical for experiments that are designed to specifically explore mitochondrial metabolism. The rAbs are optimized for IHC and western blotting of mitochondrial fractions, and we have validated these modalities for robust and reproducible performance.

Table 1. Featured anti-BIRC2 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs provides production services for the specialized area of apoptosis research using leading-edge production platforms. These state-of-the-art systems are used to express our anti-BIRC2 recombinant antibodies, optimized for accurate recognition of the native protein, and guarantee a specific and active antibody for your experiments.

Featured Anti-BIRC2 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-BIRC2 recombinant antibody production.

Fig.2 Gram-scale anti-BIRC2 recombinant antibody production.

rAb Modalities

Creative Biolabs is empowering scientific discoveries by providing antibody solutions with unparalleled flexibility. Our anti-BIRC2 recombinant antibodies are available in a variety of customizable formats to meet your research needs. Enable researchers worldwide to study this critical cell survival protein with Creative Biolabs.

Fig.3 Full-length anti-BIRC2 recombinant antibody production and modalities.

Creative Biolabs recombinant antibodies are helping researchers all over the world better understand the key roles BIRC2 plays in cell death and survival signal transduction. The hallmark of high specificity and comprehensive validation of our portfolio ensures only the best tools for your research into novel cancer therapeutics. Connect with our experts today.