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BMP7
Loading...Anti-BMP7 Products
- Recombinant Mouse Anti-Human BMP7 Antibody (MOB-1498MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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- Mouse Anti-BMP7 Recombinant Antibody (clone CBL116) (NEUT-064CQ)
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- Species Reactivity: Human
- Type: Mouse IgG2
- Application: Neut, WB, IHC
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- Mouse Anti-BMP7 Recombinant Antibody (clone CBL574) (NEUT-065CQ)
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB, IHC, Neut
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- Mouse Anti-BMP7 Recombinant Antibody (clone CBL575) (NEUT-066CQ)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IHC, ELISA(Cap), Neut
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IP
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- Derivation: Mouse
- Species Reactivity: Human, Mouse
- Type: Mouse IgG1
- Application: WB, IHC, FCM
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- Rabbit Anti-BMP7 Recombinant Antibody (VS13-YC103) (VS13-YC103)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IP
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- Anti-BMP7 Immunohistochemistry Kit (VS-0525-XY804)
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- Species Reactivity: Human
- Target: BMP7
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Jul 2016]
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Cytotrophoblasts, Oligodendrocyte precursor cells, Astrocytes, Syncytiotrophoblasts, Basal squamous epithelial cells, Squamous epithelial cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (Daudi, MCF7, OE19, RPMI-8226, SK-BR-3, U-698)
Interaction
Homodimer; disulfide-linked. Interacts with SOSTDC1 (PubMed:15020244). Interacts with TWSG1 (By similarity). Interacts with FBN1 (via N-terminal domain) and FBN2 (PubMed:18339631). Interacts with type I receptor ACVR1 (PubMed:9748228). Interacts with type II receptor ACVR2A (PubMed:12667445). Interacts with NOG; this interaction inhibits canonical BMP signaling (PubMed:12478285). Interacts with SCUBE3 (PubMed:33308444).
Molecular function
Cytokine, Developmental protein, Growth factor
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