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For Research Use Only. Not For Clinical Use.
Intracellular, Secreted (different isoforms)
Cell type enhanced (Cytotrophoblasts, Oligodendrocyte precursor cells, Astrocytes, Syncytiotrophoblasts, Basal squamous epithelial cells, Squamous epithelial cells)
Not detected in immune cells
Cell line enhanced (Daudi, MCF7, OE19, RPMI-8226, SK-BR-3, U-698)
Homodimer; disulfide-linked. Interacts with SOSTDC1 (PubMed:15020244). Interacts with TWSG1 (By similarity). Interacts with FBN1 (via N-terminal domain) and FBN2 (PubMed:18339631). Interacts with type I receptor ACVR1 (PubMed:9748228). Interacts with type II receptor ACVR2A (PubMed:12667445). Interacts with NOG; this interaction inhibits canonical BMP signaling (PubMed:12478285). Interacts with SCUBE3 (PubMed:33308444).
Cytokine, Developmental protein, Growth factor