Anti-C1QB Products

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For Research Use Only. Not For Clinical Use.

At Creative Biolabs, we understand the complexity of complement biology and have developed highly specific anti-C1QB recombinant antibodies to support your research. C1QB is an integral subunit of the C1q complex, a critical component of the classical complement pathway’s sensor that is essential for both the structural and functional integrity of the system. Creative Biolabs’ chain-specific antibodies provide the quality and validation needed to accurately study the assembly of the C1 complex and its role in human disease.

C1QB: An Essential Subunit of the C1q Complex

Complement C1q is a heterotrimeric glycoprotein, comprised of six identical copies of the A (C1QA), B (C1QB), and C (1QC) chains. The C1QB chain is a critical subunit that co-assembles with the A and C chains to form the “tulip head” structure that can recognize and bind to antibody Fc regions. Deficiencies or mutations in C1QB can preclude assembly of a functional C1q complex, which leads to defects in immune complex clearance and autoimmune diseases, most notably systemic lupus erythematosus (SLE).

Alternative Names

C1QB; Complement Component 1, Q Subcomponent, B Chain; Complement Component 1, Q Subcomponent, Beta Polypeptide

Background

C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

Anti-C1QB rAb Products

Creative Biolabs’ anti-C1QB recombinant antibodies are optimized for superior, chain-specific performance. Validated to accurately detect the C1QB chain with no cross-reactivity to the C1QA or C1QC chains, our anti-C1QB antibodies are optimized for use in applications such as Western Blot to diagnose specific C1q deficiencies or IHC to co-localize C1q subunits in tissue deposits.

Table 1. Featured anti-C1QB recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs supports the highly-specialized field of immunology with cutting-edge production platforms. Our anti-C1QB recombinant antibodies are expressed in systems optimized to produce an antibody that will accurately recognize this subunit, ensuring you have a specific and active tool for your experiments.

Featured Anti-C1QB Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-C1QB recombinant antibody production.

Fig.2 Gram-scale anti-C1QB recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to supporting scientific discovery by offering highly flexible antibody solutions. Our anti-C1QB recombinant antibodies are available in a variety of modalities to support different experimental applications and help researchers around the world study the assembly of this critical complex.

Fig.3 Full-length anti-C1QB recombinant antibody production and modalities.

Decode the assembly of the C1q complex with Creative Biolabs’ anti-C1QB recombinant antibodies. Our portfolio of highly validated chain-specific antibodies support a variety of applications and offer the specificity needed to study this important component in autoimmunity and complement biology. Trust Creative Biolabs for a reliable foundation for your research. Speak with our scientific team today.