Anti-C1QC Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is your source for world-class immunology and neuroscience research tools. Our anti-C1QC recombinant antibodies are highly pure, chain-specific antibodies to C1QC, one of three chains that make up the C1q complex. These critical proteins are responsible for the activity of the classical complement pathway, and our antibodies provide chain-specific reagents to interrogate C1q biology from autoimmunity to synaptic pruning in the brain.

C1QC: A Core Component of the C1q Sensor

Complement C1QC is one of three polypeptide chains (C1QA, C1QB, and C1QC) that form obligate trimeric complexes in the production of the C1q complex. Six copies of the C1QC chain assemble with six copies each of C1QA and C1QB chains to form the mature C1q molecule. C1q is the sensor of the classical complement pathway, and each chain is critical for structure and binding activity of the molecule. In fact, deletion of any of the three chains, including C1QC, is a high-risk factor for the development of severe systemic lupus erythematosus (SLE) due to the inability to clear apoptotic debris in the absence of the C1q-mediated pathway.

Alternative Names

C1QC; C1Q-C; Complement C1q Subcomponent Subunit C; Complement Component 1, Q Subcomponent, C Chain; C1QG

Background

C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

Anti-C1QC rAb Products

Creative Biolabs’ anti-C1QC recombinant antibodies are engineered for high affinity and chain-specificity. Each antibody is validated rigorously to demonstrate detection of the C1QC chain without cross-reactivity to C1QA or C1QB. Optimized for use in ELISA, Western Blot for diagnosis of specific deficiency, and for IHC to visualize C1q deposition in diseased tissues, Creative Biolabs rAbs are the premier research tools.

Table 1. Featured anti-C1QC recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs provides scientists with cutting-edge tools that advance research in immunology and neuroscience. Anti-C1QC recombinant antibodies are expressed in an optimized system to provide specific recognition of this subunit and high functional activity.

Featured Anti-C1QC Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-C1QC recombinant antibody production.

Fig.2 Gram-scale anti-C1QC recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to providing customizable and innovative research tools to advance research into disease mechanisms. Anti-C1QC recombinant antibodies are available in multiple modalities to provide researchers worldwide with the tools to study the assembly and function of this important pathway.

Fig.3 Full-length anti-C1QC recombinant antibody production and modalities.

Creative Biolabs’ recombinant antibodies are defined by rigorous validation and specificity. With chain-specific antibodies to C1QC, explore this important target in autoimmunity and neurodegeneration. Partner with us for antibodies that work and drive progress. Contact our specialists today.