Anti-CA14 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is a trusted provider of neuroscience research reagents and our elite anti-CA14 recombinant antibodies (rAbs) are key tools for the growing field of pH biology. As a transmembrane carbonic anhydrase with high levels of expression in the central nervous system (CNS), CA14 is an important regulator of pH in the brain and retina. Our high-quality anti-CA14 rAbs are crucial for understanding its role in neuronal excitability and pH homeostasis as well as its potential as a drug target in a range of neurological and ocular diseases.

CA14: A Transmembrane pH Regulator in the Brain

Carbonic Anhydrase 14 (CA14) is a member of the alpha-carbonic anhydrase superfamily. It is unique among the well-studied cytosolic isoforms in that it is a Type I transmembrane protein, with the catalytic domain facing the extracellular side of the cell. CA14 is also highly expressed in brain, spinal cord, and retina. As a result, by catalyzing the hydration of CO2 to bicarbonate and protons in the extracellular space, CA14 is predicted to be a key regulator of local pH in the synaptic cleft and other extracellular compartments. In turn, extracellular pH will influence the activity of a large array of pH-sensitive ion channels and receptors and as such, CA14 may play an important role in neuronal excitability.

Alternative Names

CAXiV

Background

Carbonic anhydrases (CAs) are a superfamily of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide and are involved in many biological processes, such as respiration, calcification, acid-base regulation, bone resorption, aqueous humor, cerebrospinal fluid, saliva and gastric acid production. They are widely distributed in tissues and organs, and show large diversity in their subcellular localization. CA XIV is predicted to be a type I membrane protein. The CA isoform that is most similar to CA XIV based on sequence similarity is the other transmembrane CA isoform, CA XII, and they have been shown to have different patterns of tissue-specific expression suggesting that they may have distinct physiologic roles.

Anti-CA14 rAb Products

Our anti-CA14 recombinant antibodies are selected for high affinity and specificity and then validated with care and rigor to ensure they accurately detect the CA14 protein in membrane preparations and native tissue. In addition, they are optimized for demanding applications like IHC and flow cytometry for cell-surface detection on live cells so you can have confidence in these rAbs as you perform the critical work of ion channel and neuroscience research.

Table 1. Featured anti-CA14 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

At Creative Biolabs, we are committed to helping your research move as fast as possible, which is why we use state-of-the-art production technologies for our high-quality recombinant antibodies. Our anti-CA14 recombinant antibodies are raised against the extracellular catalytic domain, making them well-suited for detecting the enzyme on live cells and for developing potential functional modulators of its activity.

Featured Anti-CA14 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CA14 recombinant antibody production.

Fig.2 Gram-scale anti-CA14 recombinant antibody production.

rAb Modalities

Creative Biolabs is also proud to be a flexible provider of research tools for the scientific community. Our anti-CA14 recombinant antibodies are available in a variety of formats that can be customized to fit your needs, including full-length IgGs and Fab fragments so researchers around the world can study this important regulator of extracellular pH.

Fig.3 Full-length anti-CA14 recombinant antibody production and modalities.

Let Creative Biolabs' high quality anti-CA14 recombinant antibodies help drive your work in studying pH regulation in the CNS. Our portfolio is designed to have exceptional specificity and is validated to the highest standard, providing you with the perfect tools for fundamental and drug discovery research. Contact our technical support specialists today to find out how we can support your critical work.