Anti-CALB1 Products

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For Research Use Only. Not For Clinical Use.

Drive neuroscientific discovery with Creative Biolabs' premium anti-CALB1 recombinant antibodies. As an important intracellular calcium-binding protein, Calbindin-D28k (CALB1) plays an important role as a calcium buffer in neurons and as a molecular marker for distinct neuronal subtypes. Creative Biolabs' top-tier anti-CALB1 recombinant antibodies are an essential tool for probing the role of CALB1 in neurodegenerative disorders, epilepsy, and the underlying biology of calcium homeostasis in the brain.

CALB1: The Major Calcium Buffer in Neurons

Calbindin 1 (CALB1), also known as Calbindin-D28k, is a cytosolic calcium-binding protein of the troponin C superfamily. CALB1 encodes a multi-calcium binding domain protein which is an effective intracellular calcium buffer. CALB1 rapidly binds free calcium ions to regulate the amplitude and duration of the calcium signal and guard against excitotoxicity, the deleterious effects of elevated intracellular calcium. CALB1 is expressed at high levels in distinct populations of neurons, including Purkinje cells of the cerebellum and dentate gyrus granule cells in the hippocampus. The selective loss of CALB1-expressing neurons is a feature of several neurodegenerative diseases, such as Huntington's and Parkinson's disease.

Alternative Names

CALB1; CAB27; CALB; Calbindin D28; D-28K; Calbindin 1, 28kDa; Calbindin; Vitamin D-Dependent Calcium-Binding Protein, Avian-Type; RTVL-H Protein

Background

CALB1 (Calbindin 1) is a Protein Coding gene. Diseases associated with CALB1 include Huntington Disease, Huntington Disease Without Motor-Dementia Phenotype, Temporal Lobe Epilepsy and Temporal Lobe Epilepsy, Benign Childhood Epilepsy with Centrotemporal Spikes. Some biological pathways that are related to CALB1 include Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Endocrine and other factor-regulated calcium reabsorption. Gene Ontology (GO) Annotations related to this gene include GO: 0005509 | calcium ion binding, GO:0005506 | vitamin D binding. A paralog of interest for this gene is CALB2.

Anti-CALB1 rAb Products

Creative Biolabs' anti-CALB1 recombinant antibodies have been engineered for superior specificity and performance. They are validated for use in key applications such as IHC and immunofluorescence to label and trace specific neuronal populations and their projections in the brain. Creative Biolabs' anti-CALB1 recombinant antibodies provide the bright and clean signal required for high-resolution neuroanatomical studies.

Table 1. Featured anti-CALB1 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs is at the forefront of research progress, and we embrace leading-edge production technologies. Our anti-CALB1 recombinant antibodies are expressed in optimized systems to ensure the highest affinity and specificity for precise neuroanatomical work.

Featured Anti-CALB1 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CALB1 recombinant antibody production.

Fig.2 Gram-scale anti-CALB1 recombinant antibody production.

rAb Modalities

Creative Biolabs is proud to offer flexible and innovative tools for the research community. Our anti-CALB1 recombinant antibodies are available in a range of customizable formats and conjugations for multi-color immunofluorescence and other advanced imaging modalities.

Fig.3 Full-length anti-CALB1 recombinant antibody production and modalities.