Anti-CALM3 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is a leader in cardiovascular genetics research, providing premier anti-CALM3 recombinant antibodies. Calmodulin 3 (CALM3) is one of three identical genes encoding the master calcium sensor, calmodulin. Mutations in this unique gene have been identified in patients with life-threatening cardiac arrhythmias. Our high-quality antibodies are essential tools for elucidating the molecular basis of calmodulinopathies and for exploring the fundamental role of calcium signaling in cardiac function.

CALM3: A Calmodulin Gene Linked to Cardiac Arrhythmias

Calmodulin 3 (CALM3) is a gene that encodes the calmodulin protein. Calmodulin is a highly conserved, small intracellular protein that functions as a calcium sensor and is encoded by three identical genes: CALM1, CALM2 and CALM3. While these genes are identical in the protein sequence they encode, they are transcribed from distinct genetic loci and are subject to independent transcriptional regulation as they are found on separate chromosomes. Calmodulin is an essential and highly conserved protein necessary for life. It interprets intracellular calcium signals and translates them into downstream effects by activating an enormous number of enzymes and ion channels in the cell. Mutations in the CALM3 gene alone have been found to cause severe cardiac diseases, including long QT syndrome and catecholaminergic polymorphic ventricular tachycardia (CPVT), suggesting a non-redundant role for each of the three calmodulin genes.

Alternative Names

CALM3; CAM2; Calmodulin 3 (Phosphorylase Kinase, Delta); CAM; CALM1 CALM2 CALM3; Epididymis Secretory Protein Li 72; CALM; Prepro-Calmodulin 3; CAMIII; CALML2; Calmodulin; CAMB; CAM1; PHKD3; CAMC

Background

The gene encodes a member of a family of calcium-binding proteins and acts as an enzymatic co-factor. The activity of this protein is important for cell cycle regulation and cytokinesis. Multiple alternatively spliced transcript variants have been observed for this gene.

Anti-CALM3 rAb Products

Our anti-calmodulin recombinant antibodies recognize the same protein product encoded by the CALM1, CALM2 and CALM3 genes. They are designed with exceptional affinity and performance in a wide range of applications. Validated extensively for Western Blot, IHC, and immunoprecipitation, these antibodies provide a highly robust and essential tool for any researcher interested in studying the molecular basis of calmodulinopathies and the role of calcium signaling in health and disease.

Table 1. Featured anti-CALM3 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

For cardiovascular research applications, Creative Biolabs uses the most advanced technologies to produce recombinant antibodies. Our anti-calmodulin recombinant antibodies are expressed in state-of-the-art systems that are optimized to ensure that the antibody recognizes the native protein, providing a highly specific and active tool for research.

Featured Anti-CALM3 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CALM3 recombinant antibody production.

Fig.2 Gram-scale anti-CALM3 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to providing flexible and innovative solutions to the research community. Our anti-calmodulin recombinant antibodies are offered in a variety of customizable modalities to accommodate a wide range of experimental needs, helping researchers all over the world to study this critical signaling protein.

Fig.3 Full-length anti-CALM3 recombinant antibody production and modalities.

Decode the intricacies of calmodulin in cardiac function with Creative Biolabs' high-quality recombinant antibodies. We are defined by our thorough validation and exceptional performance, making our antibodies the ideal tool for your research into genetic arrhythmias. Trust our expertise to power your next discovery. Contact our specialists today.