Anti-CAMKK1 Products

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For Research Use Only. Not For Clinical Use.

Dive into the complexities of neuroscience and cell signaling with Creative Biolabs' premium anti-CAMKK1 recombinant antibodies. Calcium/Calmodulin Dependent Protein Kinase Kinase 1 (CAMKK1) is an upstream kinase in the signaling cascade, responsible for activation of CaMKI and CaMKIV downstream in the module in response to calcium fluxes. The CAMKK1-mediated signaling cascade has been shown to play a modulatory role in neuronal function. Creative Biolabs' top-tier anti-CAMKK1 rAbs will help you understand the precise mechanisms that these kinases play in processes such as synaptic plasticity, neuronal development, and calcium-dependent transcription.

CAMKK1: An Upstream Kinase in Neuronal Calcium Signaling

CAMKK1 is a serine/threonine kinase that plays an upstream role in the calcium-induced signaling module that leads to activation of the downstream CAMK kinases CaMKI and CaMKIV. The calcium signal is transduced when an increase in intracellular calcium concentrations causes calcium to bind to the calcium-binding protein calmodulin. The calcium/calmodulin (CaM) complex then binds and activates CAMKK1. CAMKK1 then phosphorylates and activates CaMKI and CaMKIV. The CAMKK-CaMK signaling module has been shown to be present in the brain where it is involved in several neuronal processes, including neuronal differentiation and activity-dependent gene expression.

Alternative Names

CAMKKA

Background

The product of this gene is a member of the Serine/Threonine protein kinase family. It is also a member of the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein is a component of the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene.

Anti-CAMKK1 rAb Products

Our anti-CAMKK1 recombinant antibodies have been carefully validated to specifically detect CAMKK1 and do not cross-react with the closely homologous CAMKK2 isoform, allowing you to easily dissect out the distinct roles that these two signaling proteins play. We have optimized these rAbs for use in Western Blot of brain lysates as well as for IHC applications, allowing you to get clear and reliable data for your neuroscience research studies.

Table 1. Featured anti-CAMKK1 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

At Creative Biolabs, we use state-of-the-art production technologies to help power the most advanced neuroscience research. Our anti-CAMKK1 recombinant antibodies are produced in highly optimized systems that are engineered to make sure that the antibodies recognize the unique features of this neuronal kinase so that you get a specific and functional research tool.

Featured Anti-CAMKK1 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CAMKK1 recombinant antibody production.

Fig.2 Gram-scale anti-CAMKK1 recombinant antibody production.

rAb Modalities

Creative Biolabs prides itself on being a resource for innovative and flexible solutions for research. Our anti-CAMKK1 recombinant antibodies are available in multiple customizable modalities to help meet your diverse experimental needs and empower researchers all over the world to investigate this important signaling kinase.

Fig.3 Full-length anti-CAMKK1 recombinant antibody production and modalities.

Decode the role of CAMKK1 in neuronal signaling with Creative Biolabs' top-tier anti-CAMKK1 recombinant antibodies. The Creative portfolio stands out for its rigorous validation and unparalleled performance, making it the ideal choice for your research. Place your trust in our expertise and let us help you accelerate your next scientific breakthrough. Contact our experts today.