Anti-CAMKK2 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs understands the needs of researchers in the fields of cancer and metabolic disease, and provides outstanding anti-CAMKK2 recombinant antibodies. As one of the primary upstream kinases for both AMPK and CaMKIV, Calcium/Calmodulin Dependent Protein Kinase Kinase 2 (CAMKK2) is a master sensor of both intracellular energy and calcium levels. Our high-quality antibodies are critical for exploring its roles in cancer progression, metabolic homeostasis, and inflammation.

CAMKK2: A Master Kinase Linking Calcium and Energy Metabolism

Calcium/Calmodulin Dependent Protein Kinase Kinase 2 (CAMKK2) is a highly promiscuous serine/threonine kinase that serves as a major hub in cellular signaling pathways. It is activated in response to increases in intracellular calcium levels in a calmodulin-dependent manner. The activated CAMKK2 has two major downstream targets: (1) phosphorylation and activation of CaMKI/IV pathway, and (2) CAMKK2 is a major upstream kinase for AMP-activated protein kinase (AMPK), the master regulator of intracellular energy homeostasis. In this way, CAMKK2 links calcium signaling to AMPK directly and functions as an important mediator of metabolism, inflammation, and cell growth. It is overexpressed and tumor-promoting in a number of cancers, including prostate cancer, and is a major target for therapeutic intervention.

Alternative Names

CAMKK; CAMKKB

Background

This gene encodes a class I protein methyltransferase that acts in the formation of trimethyllysine in calmodulin. The protein contains a AdoMet-binding motif and may play a role in calcium-dependent signaling. [provided by RefSeq, Sep 2012]

Anti-CAMKK2 rAb Products

Our anti-CAMKK2 recombinant antibodies are engineered for the highest specificity and have been thoroughly validated for use in detecting CAMKK2 with no cross reactivity for the CAMKK1 isoform. This is critical for specifically studying the functions of CAMKK2. Furthermore, this antibody has been optimized for Western Blot, IHC, and kinase assays. These rAbs will provide the reliability and specificity your research requires as you investigate the key roles of this enzyme in metabolic and oncology research.

Table 1. Featured anti-CAMKK2 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

To better serve the unique needs of the metabolic research community, Creative Biolabs maintains state of the art production platforms. We use optimized expression systems for our anti-CAMKK2 recombinant antibodies so they are fully capable of recognizing the native kinase with high specificity, and produce a highly specific and active antibody for your research.

Featured Anti-CAMKK2 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CAMKK2 recombinant antibody production.

Fig.2 Gram-scale anti-CAMKK2 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to enabling scientific discoveries by providing a variety of flexible antibody modalities. Our anti-CAMKK2 recombinant antibodies are available in a variety of customizable modalities to accommodate your experimental needs, no matter what approach you take in investigating this important signaling hub.

Fig.3 Full-length anti-CAMKK2 recombinant antibody production and modalities.

Explore the important roles of CAMKK2 in both cancer and metabolism with the best quality recombinant antibodies from Creative Biolabs. We are well known for our high specificity products that are thoroughly validated to provide you with the best tools for your research into this key target. Contact our experts today and experience our quality, which is designed to accelerate your work.