Anti-CAPNS1 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is your trusted source for protease research, and we are proud to offer premium anti-CAPNS1 recombinant antibodies. CAPNS1 is the indispensable small regulatory subunit for the two major, ubiquitously expressed calpain proteases, calpain-1 (CAPN1) and calpain-2 (CAPN2). It is a key determinant of their stability and activity. We make high-quality antibodies for you to study calpain biology and understand its involvement in neurodegeneration, cardiovascular disease, and cancer.

CAPNS1: The Essential Regulator of Conventional Calpains

Calpain Small Subunit 1 (CAPNS1), also known as CSS1, is the 28 kDa regulatory subunit that is an obligate binding partner for the two major, ubiquitously expressed calpain catalytic subunits, calpain-1 (CAPN1) and calpain-2 (CAPN2). CAPNS1 is absolutely required for the stability and proper function of these proteases. It is needed to form the active heterodimer and modulates the calcium sensitivity of the complex. CAPN1 and CAPN2 are widely implicated in a variety of cellular processes including cell migration, invasion, cell cycle, apoptosis and excitotoxic cell death. The essential regulator of these conventional calpains, CAPNS1, is a critical player in calpain biology.

Alternative Names

CANP; CDPS; CSS1; PPH6; CANPS; CAPN4; CALPAIN4

Background

CAPNS1 (Calpain Small Subunit 1) is a Protein Coding gene. Diseases related to CAPNS1 include Chronic Neutrophilic Leukemia. Some of its related pathways are Apoptosis Modulation and Signaling and Keratinization. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium-dependent cysteine-type endopeptidase activity. CAPNS2 is a relevant paralog of this gene.

Anti-CAPNS1 rAb Products

Our anti-CAPNS1 recombinant antibodies are designed with your research in mind. High in specificity and performance, they are extensively validated to detect with accuracy the small subunit of the calpain complex. Optimized for applications such as Western Blot to measure its expression or co-immunoprecipitation to study the assembly of the calpain heterodimer, our rAbs deliver the dependability and precision you need for protease research.

Table 1. Featured anti-CAPNS1 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

To meet the needs of protease research, Creative Biolabs employs a robust antibody production platform that incorporates only the best technologies and practices. We use optimized expression systems for our anti-CAPNS1 recombinant antibodies, so they will accurately recognize the native protein and provide a highly specific and active antibody for your research.

Featured Anti-CAPNS1 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CAPNS1 recombinant antibody production.

Fig.2 Gram-scale anti-CAPNS1 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to driving innovation, and one of the ways we help is by providing flexible antibody solutions. Our anti-CAPNS1 recombinant antibodies are available in several customizable modalities to fit the needs of your research.

Fig.3 Full-length anti-CAPNS1 recombinant antibody production and modalities.

Probe the important functions of the calpain system with Creative Biolabs' anti-CAPNS1 recombinant antibodies. High in specificity and rigorously validated, our product line is designed to deliver the ideal reagents for your research. Choose quality that advances discovery with us by your side. Talk to our experts today.