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CAPZB
Anti-CAPZB Recombinant Antibody Products
- AbPlus™ Anti-CAPZB Magnetic Beads (VS-0724-YC1161) (VS-0724-YC1161)
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- Target: CAPZB
- Target Species: Human
- Application: IP, Protein Purification
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- Anti-CAPZB Immunohistochemistry Kit (VS-0325-XY316)
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- Species Reactivity: Human, Mouse, Rat
- Target: CAPZB
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes an actin capping protein, one of the F-actin capping protein alpha subunit family. The encoded protein is predominantly localized to the neck region of ejaculated sperm, other immunohistochemical signals were found in the tail and postacrosomal regions. The encoded protein may also form heterodimers of alpha and beta subunits. This protein may be important in determining sperm architecture and male fertility. [provided by RefSeq, Jul 2008]
Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Late spermatids, Early spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Heterodimer of an alpha and a beta subunit. Interacts with ARHGAP17 (PubMed:16678097). Interaction with RCSD1/CAPZIP (PubMed:15850461). Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASHC1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), WASHC2 (WASHC2A or WASHC2C), WASHC3, WASHC4 and WASHC5 (PubMed:19922875). Interacts with ACTG1 (PubMed:28493397). Directly interacts with CRACD; this interaction decreases binding to actin (PubMed:30361697).
Molecular function
Actin capping, Actin-binding
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