CARD8

Human disease related genes

Intracellular

Cell type enhanced (Adipocytes)

Low immune cell specificity

Cell line enhanced (HEL, HUVEC TERT2, NB-4, TIME)

Interacts with DPP9; leading to inhibit activation of the inflammasome (PubMed:31525884, PubMed:33731929, PubMed:34019797). DPP9 acts via formation of a ternary complex, composed of a DPP9 homodimer, one full-length CARD8 protein, and one cleaved C-terminus of CARD8 (Caspase recruitment domain-containing protein 8, C-terminus) (PubMed:34019797). Interacts with DPP8; leading to inhibit activation of the inflammasome, probably via formation of a ternary complex with DPP8 (PubMed:31525884). Interacts with NLRP3 (PubMed:24517500). Interacts with IKBKG/NEMO (PubMed:11551959). Interacts with DRAL (PubMed:12067710). Binds to caspase-1 (CASP1), CARD16/pseudo-ICE and CARD18/ICEBERG (PubMed:11821383). Interacts with NLRP2 (via NACHT domain) (PubMed:15030775). [Caspase recruitment domain-containing protein 8, N-terminus]: Interacts with the C-terminal part of CARD8 (Caspase recruitment domain-containing protein 8, C-terminus) in absence of pathogens and other damage-associated signals. [Caspase recruitment domain-containing protein 8, C-terminus]: Interacts with the N-terminal part of CARD8 (Caspase recruitment domain-containing protein 8, N-terminus) in absence of pathogens and other damage-associated signals (PubMed:33542150). Homomultimer; forms the CARD8 inflammasome polymeric complex, a filament composed of homopolymers of this form in response to pathogens and other damage-associated signals (PubMed:33420028, PubMed:33420033). The CARD8 inflammasome polymeric complex directly recruits pro-caspase-1 (proCASP1) independently of PYCARD/ASC (PubMed:32051255). Interacts (via CARD domain) with CASP1 (via CARD domain); leading to CASP1 activation (PubMed:33542150, PubMed:33420033).

Hydrolase, Protease