Anti-CASQ1 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is your trusted partner in muscle physiology research. Providing the highest quality anti-CASQ1 recombinant antibodies, we are proud to be at the forefront of your quest to study these proteins. Calsequestrin-1 (CASQ1) is the main calcium-buffering protein in the sarcoplasmic reticulum of skeletal muscle. It is required for excitation-contraction coupling. Our antibodies are the ideal research tool for the study of muscle diseases such as malignant hyperthermia and myopathies, as well as fundamental aspects of muscle function.

CASQ1: The Calcium Reservoir of Skeletal Muscle

Calsequestrin-1 (CASQ1) is a high-capacity, moderate-affinity calcium-binding protein that resides in the terminal cisternae of the sarcoplasmic reticulum (SR) of skeletal muscle. The protein serves as a calcium sink to facilitate storage of the massive amounts of calcium needed for muscle contraction at very low free calcium concentrations. The protein also likely modulates activity of the ryanodine receptor calcium release channel through polymerization that is dependent on calcium. Mutations in CASQ1 cause vacuolar aggregate myopathy and predispose patients to malignant hyperthermia, a life-threatening reaction to certain anesthetics.

Alternative Names

CASQ1; Calsequestrin-1; PDIB1; Calmitin; Calsequestrin 1 (Fast-Twitch, Skeletal Muscle); VMCQA; Skeletal Muscle; Calmitine; CASQ; Calsequestrin 1; Fast-Twitch

Background

The protein encoded by this gene is the skeletal muscle specific member of the calsequestrin protein family. Calsequestrin is a luminal sarcoplasmic reticulum calcium sensor in cardiac and skeletal muscle cells. The protein encoded by this gene, also known as calmitine, is a calcium regulator of mitochondria in skeletal muscle. This protein is absent in the Duchenne and Becker type of muscular dystrophy.

Anti-CASQ1 rAb Products

Our recombinant anti-CASQ1 antibodies are designed to be as specific as possible. We take special care to validate that our antibody detects only the skeletal muscle isoform without cross-reacting with the similar cardiac muscle isoform (CASQ2), a detail of vital importance in muscle-specific research. We further optimized our rAbs for Western Blot of muscle lysates as well as for IHC to study its localization in the SR.

Table 1. Featured anti-CASQ1 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

We understand the need for powerful and dependable tools to enable the most advanced research in muscle biology. To meet this need, Creative Biolabs leverages state-of-the-art production technologies to develop our anti-CASQ1 recombinant antibodies. Our proprietary expression systems have been optimized to ensure our antibodies closely recognize the native protein, providing you with a highly specific and active research tool for your experiments.

Featured Anti-CASQ1 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CASQ1 recombinant antibody production.

Fig.2 Gram-scale anti-CASQ1 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to advancing scientific research. We understand that many different research scenarios require flexibility to meet individual experimental needs. That is why our anti-CASQ1 recombinant antibodies are available in a variety of customizable modalities to support a wide range of applications for researchers around the world as they work to better understand the inner workings of muscle contraction.

Fig.3 Full-length anti-CASQ1 recombinant antibody production and modalities.

Learn more about CASQ1's essential role in skeletal muscle with the superior quality of Creative Biolabs recombinant antibodies. Built on high specificity and comprehensive validation, our antibodies provide the ideal tools for your research into myopathies and other aspects of calcium handling in the sarcolemma. Trust us for quality that fuels discovery. Contact our experts today.