Anti-CATSPER1 Recombinant Antibody Products
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Loading...- Recombinant Anti-Human CATSPER1 Antibody (MOB-3285z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, IF, FuncS
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For Research Use Only. Not For Clinical Use.
Creative Biolabs creates state-of-the-art anti-CATSPER1 recombinant antibodies for advanced reproductive biology research. Targeting CATSPER1, a pore-forming subunit of the principal calcium channel of sperm, is critical for uncovering the mechanisms underlying sperm activation, male infertility, and to design novel, non-hormonal male contraceptives.
CATSPER1: The Gatekeeper of Sperm Calcium Influx
The Cation Channel of Sperm 1 (CATSPER1) is the pore-forming alpha subunit of the CatSper ion channel complex. Found exclusively in the principal piece of the sperm tail, CatSper is the main calcium channel in sperm. The channel is both pH and voltage sensitive and activated in the presence of approaching eggs, resulting in a large Ca2+ influx. This increase in intracellular calcium levels induces the hyperactivated motility necessary to penetrate the egg’s protective barriers. Mutations that cause a loss of function in CATSPER1 leave sperm unable to hyperactivate, resulting in male infertility.
Alternative Names
CATSPER1; CatSper1; Sperm-Associated Cation Channel 1; Sperm Ion Channel; Cation Channel Sperm-Associated Protein 1; HCatSper
Background
Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Transporters
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (granulocytes, Early spermatids, NK-cells, monocytes, Hofbauer cells)
Immune cell specificity
Immune cell enhanced (basophil)
Cell line specificity
Cell line enhanced (CAPAN-2, EFO-21, HEL, HMC-1)
Interaction
Component of the CatSper complex or CatSpermasome composed of the core pore-forming members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 as well as auxiliary members CATSPERB, CATSPERG, CATSPERD, CATSPERE, CATSPERZ, TMEM249, TMEM262 and EFCAB9 (By similarity). HSPA1 may be an additional auxiliary complex member (By similarity). The core complex members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 form a heterotetrameric channel (By similarity). The auxiliary CATSPERB, CATSPERG, CATSPERD and CATSPERE subunits form a pavilion-like structure over the pore which stabilizes the complex through interactions with CATSPER4, CATSPER3, CATSPER1 AND CATSPER2 respectively (By similarity). TMEM262/CATSPERH interacts with CATSPERB, further stabilizing the complex (By similarity). Interacts with Ca(v)3.3/CACNA1I, leading to suppression of T-type calcium channel activity (PubMed:16740636).
Molecular function
Calcium channel, Developmental protein, Ion channel, Voltage-gated channel
More Types Infomation
Anti-CATSPER1 rAb Products
Creative Biolabs’ anti-CATSPER1 recombinant antibodies are highly specific and robustly perform. Validated to detect CATSPER1 in sperm lysates and tissue sections, our antibodies are optimized for applications like immunofluorescence to visualize localization of the channel to the sperm tail or Western Blot to detect expression levels.
Table 1. Featured anti-CATSPER1 recombinant antibody products at Creative Biolabs.
| Cat. No. | Product Name | Target Species | Host Species | Applications |
| MOB-3285z | Recombinant Anti-Human CATSPER1 Antibody | Human | Mouse IgG | ELISA, IF, FuncS |
Customer Reviews
Excellent
G**ryRecombinant Anti-Human CATSPER1 Antibody
We are screening for male contraceptives that inhibit CatSper and this antibody has been crucial for us to validate target expression in our assays. Highly specific and a very reliable product.
11/Jul/2024
rAb Production
To advance reproductive biology research, Creative Biolabs utilizes a proprietary antibody production platform. Our anti-CATSPER1 recombinant antibodies are expressed in highly optimized systems to ensure they reliably recognize this multi-pass transmembrane protein, yielding a highly specific antibody for your research.
Featured Anti-CATSPER1 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CATSPER1 recombinant antibody production.
Fig.2 Gram-scale anti-CATSPER1 recombinant antibody production.
rAb Modalities
Creative Biolabs is committed to facilitating scientific discovery with a diverse portfolio of customizable antibody modalities. Our anti-CATSPER1 recombinant antibodies are available in multiple formats to enable investigators everywhere to research this key ion channel.
Fig.3 Full-length anti-CATSPER1 recombinant antibody production and modalities.
Explore the key roles of CATSPER1 in fertility with the high quality of Creative Biolabs’ recombinant antibodies. Defined by high specificity and extensive validation, our portfolio is optimized to be the right tool for your research into contraception and male infertility. Collaborate with us for the quality that will expedite your discoveries. Contact our experts today.