Anti-CBS Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is a trusted supplier of metabolic disease research. We understand your needs for premium anti-CBS recombinant antibodies. As the rate-limiting enzyme in the transsulfuration pathway, Cystathionine Beta-Synthase (CBS) is a critical enzyme in homocysteine metabolism and hydrogen sulfide (H2S) production. Our high-quality antibodies will be an important research tool for studying homocystinuria, Alzheimer’s disease, and H2S signaling.

CBS: A Master Regulator of Sulfur Metabolism

Cystathionine Beta-Synthase (CBS) is a pyridoxal phosphate (vitamin B6)-dependent enzyme that catalyzes the first step in the transsulfuration pathway, the condensation of homocysteine and serine to form cystathionine. This pathway accounts for the majority of homocysteine clearance, a toxic metabolite, and is the predominant source of the gaseous signaling molecule hydrogen sulfide (H2S) in the liver and brain. Homocystinuria, a severe inherited metabolic disease caused by loss-of-function mutations in the CBS gene is defined by an increase in plasma homocysteine leading to intellectual disability, skeletal deformities, and vascular disease.

Alternative Names

CBS; Serine Sulfhydrase; Beta-Thionase; Cystathionine-Beta-Synthase; HIP4; EC 4.2.1.22; Methylcysteine Synthase

Background

The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. Multiple alternatively spliced transcript variants have been found for this gene.

Anti-CBS rAb Products

To best support your studies, our anti-CBS recombinant antibodies are carefully engineered to be high specificity and high performance tools. We strictly validate each lot to ensure accurate detection of your target enzyme. Optimized for your Western Blot applications to verify homocystinuria diagnosis in patient fibroblasts, or your IHC studies to evaluate tissue distribution, our rAbs are a reliable choice for your metabolic research.

Table 1. Featured anti-CBS recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs has established reliable antibody solutions to advance your work in this specialized field of metabolic research. Our anti-CBS recombinant antibodies are expressed in optimized systems to make sure they recognize the native enzyme for a highly specific and active research tool.

Featured Anti-CBS Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CBS recombinant antibody production.

Fig.2 Gram-scale anti-CBS recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to helping scientists create new discoveries. We offer our anti-CBS recombinant antibodies in several modalities that are customizable to meet your exact experimental requirements. Partner with us today to study this important metabolic enzyme.

Fig.3 Full-length anti-CBS recombinant antibody production and modalities.

Get to the bottom of CBS critical roles in homocysteine and H2S metabolism using Creative Biolabs recombinant antibodies of superior quality. You will find the strict validation and consistency you need to study this important enzyme in homocystinuria and neurologic disorders. Trust us to provide a strong foundation for your research and contact our specialists today.