Disease related genes, Potential drug targets, Transporters
Intracellular, Membrane (different isoforms)
Low cell type specificity
Low immune cell specificity
Low cell line specificity
The PAT complex includes WDR83OS/Asterix and CCDC47 (PubMed:32814900). The ribosome-associated ER translocon complex includes SEC61A1, SEC61B, SEC61G, TMCO1, CCDC47, NCLN/Nicalin, NOMO and TMEM147; in the absence of ribosomes, only the complex forms with NCLN/Nicalin, NOMO and TMEM147 remains intact (PubMed:32820719). Interacts with VCP, HSPA5, DERL1, DERL2 and SELENOS (By similarity).
Chaperone
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For Research Use Only. Not For Clinical Use.