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    For Research Use Only. Not For Clinical Use.


    Creative Biolabs provides top-tier recombinant antibodies for immunology and drug discovery research. Targeting the chemokine receptor CCR1, our anti-CCR1 rAbs are a powerful tool for understanding leukocyte trafficking and inflammation and for developing new immunomodulatory drugs.

    CCR1: A Key Driver of Monocyte Recruitment

    CCR1 is a major target for the development of immunomodulatory therapeutics for autoimmune diseases. A key driver of monocyte and other immune cell recruitment to sites of inflammation, CCR1 is a major therapeutic target in many chronic autoimmune disorders characterized by aberrant immune cell infiltration, such as rheumatoid arthritis and multiple sclerosis. Creative Biolabs' top-tier antibodies are an important tool for characterizing the role of CCR1 in leukocyte trafficking, inflammation, and autoimmune diseases and for screening novel drugs.

    Alternative Names

    C-C Motif Chemokine Receptor 1; Macrophage Inflammatory Protein 1-Alpha Receptor; Chemokine (C-C Motif) Receptor 1; LD78 Receptor; MIP-1alpha-R; C-C CKR-1; CC-CKR-1; RANTES-R; CMKBR1; SCYAR1; CCR-1;

    Background

    CCR1 (C-C Motif Chemokine Receptor 1) is a Protein Coding gene. Diseases associated with CCR1 include Immune-Complex Glomerulonephritis and Chromoblastomycosis. Among its related pathways are Cytokine Signaling in Immune system and Akt Signaling. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity. An important paralog of this gene is CCR3.

    Protein class

    CD markers, G-protein coupled receptors, Human disease related genes

    Predicted location

    Membrane

    Single cell type specificity

    Group enriched (Kupffer cells, Hofbauer cells, Extravillous trophoblasts, Macrophages, monocytes)

    Immune cell specificity

    Low immune cell specificity

    Cell line specificity

    Cell line enhanced (Karpas-707, RPMI-8226, U-266/70, U-266/84)

    Interaction

    Interacts with CREB3.

    Molecular function

    G-protein coupled receptor, Receptor, Transducer

    More Types Infomation

    Anti-CCR1 rAb Products

    Creative Biolabs’ anti-CCR1 recombinant antibodies are designed to bind with high affinity and high specificity to the native conformation of the receptor’s extracellular domains. They are validated for specifically and reliably detecting CCR1 on the surface of primary immune cells. Optimized for sensitive and reliable detection in multi-color flow cytometry, IHC on inflamed tissues, and for use in functional chemotaxis assays, our recombinant antibodies are top-quality tools for immunology and drug discovery.

    Table 1. Featured anti-CCR1 recombinant antibody products at Creative Biolabs.

    Cat. No. Product Name Target Species Host Species Applications
    HPAB-M0354-YC Human Anti-CCR1 Recombinant Antibody (HPAB-M0354-YC) Human, Mouse Human IgG4 FC, Inhib
    HPAB-M0338-YC Mouse Anti-CCR1 Recombinant Antibody (HPAB-M0338-YC) Human, Mouse Mouse IgG2a FC, FuncS, IHC, IF, Inhib
    NABL-077 Recombinant Anti-human CCR1 VHH Single Domain Antibody Human Llama VHH WB, ELISA, IP, FuncS

    Customer Reviews

    Excellent
    K**th
    Mouse Anti-CCR1 Recombinant Antibody (HPAB-M0338-YC)
    We’re working on CCR1 antagonists and this antibody has been a game-changer for our binding and receptor internalization assays. It’s an outstanding, reliable product for any GPCR researcher.
    10/Sep/2023

    rAb Production

    To help drive discovery in drug discovery research, Creative Biolabs leverage next-generation production technologies. Our anti-CCR1 recombinant antibodies are expressed in such a way that they bind to the native conformation of the extracellular domains of the receptor. As a result, they are ideal for functional studies and for screening receptor antagonists.

    Featured Anti-CCR1 Recombinant Antibody Production PlatformsFig.1 Milligram-scale. (Creative Biolabs Original)
    Fig.1 Milligram-scale anti-CCR1 recombinant antibody production.

    Fig.2 Gram-scale. (Creative Biolabs Original)Fig.2 Gram-scale anti-CCR1 recombinant antibody production.

    rAb Modalities

    Creative Biolabs is all about delivering innovative, flexible tools to empower the research community. Our anti-CCR1 recombinant antibodies are available in a range of formats to suit your project, including full-length IgGs for in vivo blocking and neutralization studies, and Fabs for structural biology.

    Fig.3 CCR1 antibody production and modalities. (Creative Biolabs Original)Fig.3 Full-length anti-CCR1 recombinant antibody production and modalities.

    CCR1-Targeted Drug Information

    Table 2. Public drug targeting CCR1.

    Company Research Phase Classification Condition
    ChemoCentryx Approved (for ANCA Vasculitis) Small Molecule Antagonist (Also targets C5aR, but shows CCR1 activity)
    GSK Terminated (Phase 3 for Crohn's) Small Molecule Antagonist Inflammatory Bowel Disease
    Bristol Myers Squibb Phase 1 (Terminated) Monoclonal Antibody Rheumatoid Arthritis
    Millennium/Takeda Phase 2 (Terminated) Monoclonal Antibody Multiple Sclerosis, Atherosclerosis

    (Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

    Accelerate your research in inflammation with Creative Biolabs’ top-quality anti-CCR1 recombinant antibodies. Our products are characterized by high specificity, sensitivity, and rigorous validation to ensure you get the most reliable tools for your fundamental and translational research. Don’t take chances on substandard reagents. Trust Creative Biolabs to deliver the antibodies you need for your important work. Get in touch with our experts today.

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