Anti-CDC7 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs can support your research on oncology and cell cycle with highly specific anti-CDC7 recombinant antibodies. Cell Division Cycle 7-Related Protein Kinase (CDC7) is the key kinase that initiates DNA replication and acts as a stringent gatekeeper of the cell cycle. Targeted inhibition of CDC7 activity is an emerging strategy for the treatment of cancer. Our high-quality antibodies are a key tool for understanding the biology of DNA synthesis and for preclinical drug discovery targeting this essential kinase.

CDC7: The Initiator of DNA Replication

Cell Division Cycle 7-Related Protein Kinase (CDC7), commonly referred to as CDC7, is a serine/threonine kinase that is critical for the initiation of DNA replication. It is tightly regulated during the cell cycle, with its activity peaking at the G1/S transition. Its primary function is to phosphorylate a number of the subunits of the MCM (minichromosome maintenance) complex, which is the core helicase at replication origins. This is the “firing” signal that activates the MCM helicase, which loads the DNA replication machinery and initiates synthesis. Many cancer cells are under replicative stress, and thus are particularly sensitive to the inhibition of CDC7, making it an attractive target.

Alternative Names

Cell Division Cycle 7; CDC7 (Cell Division Cycle 7, S. Cerevisiae, Homolog)-Like 1; CDC7-Related Kinase; HsCDC7; HuCDC7; CDC7L1; Cell Division Cycle 7 Homolog (S. Cerevisiae); Cell Division Cycle 7-Related Protein Kinase;

Background

CDC7 (Cell Division Cycle 7) is a Protein Coding gene. Among its related pathways are E2F mediated regulation of DNA replication and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.

Anti-CDC7 rAb Products

Creative Biolabs’ anti-CDC7 recombinant antibodies are designed with specificity and performance in mind. Our anti-CDC7 rAbs are extensively validated to specifically detect the CDC7 kinase in nuclear extracts. Optimized for use in Western Blot for monitoring expression levels, or for immunoprecipitation and in vitro kinase assays, our recombinant antibodies are a reliable choice for cell cycle research and drug discovery.

Table 1. Featured anti-CDC7 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs has a modern, versatile antibody production platform that can support the niche field of oncology. Our anti-CDC7 recombinant antibodies are produced in an optimized expression system to ensure that they recognize the native form of the enzyme, so you have the highest confidence in the specificity and activity of this tool in your demanding experiments.

Featured Anti-CDC7 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CDC7 recombinant antibody production.

Fig.2 Gram-scale anti-CDC7 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to providing the tools and resources that you need to drive scientific discovery. Our anti-CDC7 recombinant antibodies are available in a variety of modalities to choose from so you can customize your reagent to best fit your experiments. Drive your research forward with Creative Biolabs’ powerful and flexible antibody solutions.

Fig.3 Full-length anti-CDC7 recombinant antibody production and modalities.

Gain precise insights into the biology of DNA replication with Creative Biolabs’ anti-CDC7 recombinant antibodies. We are focused on rigorous validation and consistency, so you can trust us to give you a strong foundation for your important work. Our team of scientific experts are standing by to help you choose the right reagents. Please get in touch today.