Anti-CDK7 Products

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For Research Use Only. Not For Clinical Use.

As the CDK that activates RNA Polymerase II, Cyclin-Dependent Kinase 7 (CDK7) is the master regulator of transcription. Creative Biolabs’ top-quality anti-CDK7 recombinant antibodies are essential for dissecting the mode of action of emerging transcriptional inhibitors. They are also an effective way to study the cell cycle and DNA repair pathways.

CDK7: The Master Kinase of Transcription and Cell Cycle

Cyclin-Dependent Kinase 7 (CDK7) is a serine/threonine kinase with two related but distinct functions in the cell. First, as the catalytic subunit of the CDK-Activating Kinase (CAK) complex, CDK7 serves as the global on/off switch for cell cycle progression. Second, and most importantly, CDK7 is also a subunit of the Transcription Factor II H (TFIIH) complex, where it phosphorylates the C-Terminal Domain (CTD) of RNA Polymerase II. This is the essential step that releases Pol II from the promoter for productive elongation. As CDK7 acts as the global gatekeeper for transcription across the entire genome, it is an effective way to take down the entire oncogenic network.

Alternative Names

Cyclin Dependent Kinase 7; Cyclin-Dependent Kinase 7 (MO15 Homolog, Xenopus Laevis, Cdk-Activating Kinase); TFIIH Basal Transcription Factor Complex Kinase Subunit; Cell Division Protein Kinase 7; CDK-Activating Kinase 1; 39 KDa Protein Kinase; EC 2.7.11.22; CDKN7; STK1; CAK1; MO15; CAK; Cyclin-Dependent Kinase 7 (Homolog Of Xenopus MO15 Cdk-Activating Kinase); Homolog Of Xenopus MO15 Cdk-Activating Kinase

Background

The protein encoded by this gene is a member of the cyclin dependent protein kinase (CDK) family. Members of the CDK family are closely related to the gene products of the Saccharomyces cerevisiae cdc28 and Schizosaccharomyces pombe cdc2 and have been shown to be important regulators of cell cycle progression. This protein is part of a trimeric complex with cyclin H and MAT1 that functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, which participates in transcription initiation and DNA repair. This protein may provide a direct link between transcription regulation and the cell cycle.

Anti-CDK7 rAb Products

Creative Biolabs’ anti-CDK7 recombinant antibodies are designed with precision and built for maximum performance. Each antibody is carefully validated for specificity to accurately detect CDK7 kinase. Optimized for use in Western Blot, Immunoprecipitation, and Chromatin Immunoprecipitation (ChIP), our rAbs provide unparalleled specificity to study this highly rate-limiting enzyme.

Table 1. Featured anti-CDK7 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs uses the latest production technologies for high-quality anti-CDK7 recombinant antibodies. Our proprietary expression systems are carefully optimized to ensure antibodies recognize the native protein with high specificity, providing you a specific and active tool for your research.

Featured Anti-CDK7 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CDK7 recombinant antibody production.

Fig.2 Gram-scale anti-CDK7 recombinant antibody production.

rAb Modalities

Creative Biolabs supports research scientists in their groundbreaking work by providing multiple modalities of antibodies. Our anti-CDK7 recombinant antibodies are available in a variety of customizable formats to empower researchers across the world to study this important transcriptional kinase.

Fig.3 Full-length anti-CDK7 recombinant antibody production and modalities.

Creative Biolabs provides top-quality anti-CDK7 recombinant antibodies for high-throughput screening, ChIP, Western blot, and other immunodetection applications. Optimized and rigorously validated for specificity and performance, Creative Biolabs’ anti-CDK7 rAbs give you the consistency needed to dissect this important therapeutic target in oncology. Rely on our expertise to lay the groundwork for your research. Please contact our experts today.