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CDON
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis.
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Excitatory neurons, Inhibitory neurons, Muller glia cells, Fibroblasts)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (AF22, ASC diff, RH-30, SuSa)
Interaction
Part of a complex that contains BOC, CDON, NEO1, cadherins and CTNNB1. Interacts with NTN3 (By similarity). Interacts with PTCH1 (By similarity). Interacts with GAS1 (By similarity). Interacts with DHH, IHH and SHH.
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