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CFLAR
Loading...Anti-CFLAR Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, FC, ICC, IF, IHC
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- Derivation: Phage display library
- Species Reactivity: Mouse, Rat, Human
- Type: Rabbit IgG
- Application: WB, IHC-P, ICC, IF
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- Anti-CFLAR Immunohistochemistry Kit (VS-0325-XY435)
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- Species Reactivity: Human
- Target: CFLAR
- Application: IHC
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- Anti-Mouse CFLAR Immunohistochemistry Kit (VS-0525-XY1403)
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- Species Reactivity: Human, Mouse, Rat
- Target: CFLAR
- Application: IHC
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More Infomation
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For Research Use Only. Not For Clinical Use.
Background
The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8.
Protein class
Cancer-related genes, Enzymes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Langerhans cells, Urothelial cells)
Immune cell specificity
Immune cell enriched (neutrophil)
Cell line specificity
Cell line enhanced (U-266/70)
Interaction
TNFRSF6 stimulation triggers recruitment to the death-inducing signaling complex (DISC) formed by TNFRSF6, FADD and CASP8 (PubMed:9880531). A proteolytic fragment (p43) stays associated with the DISC (PubMed:9880531). Also interacts with FADD, CASP8, CASP3, TRAF1, TRAF2 and Bcl-X(L) (in vitro) (PubMed:9326610, PubMed:9208847). Interacts with RIPK1 (By similarity) (PubMed:9326610, PubMed:9208847, PubMed:9880531). (Microbial infection) Interacts with HBV protein X.
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