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CHAF1A
Anti-CHAF1A Recombinant Antibody Products
- Rabbit Anti-CHAF1A Recombinant Antibody (clone JG38-98) (MRO-1139-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IP, IHC, FC
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For Research Use Only. Not For Clinical Use.
Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Spermatogonia, Spermatocytes, Erythroid cells)
Immune cell specificity
Immune cell enhanced (plasmacytoid DC)
Cell line specificity
Low cell line specificity
Interaction
Homodimer. Part of the CAF-1 complex that contains RBBP4, CHAF1B and CHAF1A. CHAF1A binds directly to CHAF1B. Only minor amounts of RBBP4 are complexed with CHAF1A and CHAF1B in G1 phase. CHAF1A binds directly to PCNA and to CBX1. Interacts with MBD1 (PubMed:12697822). Interacts directly with CBX5 via the PxVxL motif. Interacts with CBX5. Interacts with histones H3.1, H3.2 and H3.1t (PubMed:33857403).
Molecular function
Chaperone
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