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CHAF1B
Loading...Anti-CHAF1B Products
- Rabbit Anti-CHAF1B Recombinant Antibody (clone JG92-30) (MRO-1155-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IP, IHC, FC
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: FC, ICC, IHC-P, IP, WB
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- Anti-CHAF1B Immunohistochemistry Kit (VS-0325-XY438)
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- Species Reactivity: Human
- Target: CHAF1B
- Application: IHC
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- Anti-Mouse CHAF1B Immunohistochemistry Kit (VS-0525-XY1415)
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- Species Reactivity: Human, Mouse, Rat, Canine, Monkey
- Target: CHAF1B
- Application: IHC
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- Anti-Human CHAF1B Immunohistochemistry Kit (VS-0525-XY1414)
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- Species Reactivity: Human
- Target: CHAF1B
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
Chromatin assembly factor I (CAF-I) is required for the assembly of histone octamers onto newly-replicated DNA. CAF-I is composed of three protein subunits, p50, p60, and p150. The protein encoded by this gene corresponds to the p60 subunit and is required for chromatin assembly after replication. The encoded protein is differentially phosphorylated in a cell cycle-dependent manner. In addition, it is normally found in the nucleus except during mitosis, when it is released into the cytoplasm. Diseases associated with CHAF1B include Attention Deficit-Hyperactivity Disorder and Luminal Breast Carcinoma A.
Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Spermatocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Subunit of the CAF-1 complex that contains RBBP4, CHAF1B and CHAF1A. CHAF1A binds directly to CHAF1B. Only minor amounts of RBBP4 are complexed with CHAF1A and CHAF1B in G1 phase. In G2 and S phase also monomeric CHAF1B is detected. Interacts with histones H3.1, H3.2 and H3.1t (PubMed:33857403).
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