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CHN1
Loading...Anti-CHN1 Products
- Mouse Anti-NHP CHN1 Recombinant Antibody (clone OTI3C6) (VS-1024-XY122)
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- Species Reactivity: Dog, Human, Mouse, Non-human primate, Rat
- Type: Mouse IgG1
- Application: WB, IHC
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- Anti-CHN1 Immunohistochemistry Kit (VS-0525-XY1445)
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- Species Reactivity: Human
- Target: CHN1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duane's retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Excitatory neurons, Astrocytes, Oligodendrocyte precursor cells, Inhibitory neurons, Microglial cells)
Immune cell specificity
Group enriched (T-reg, memory CD4 T-cell, memory CD8 T-cell)
Cell line specificity
Cell line enhanced (BJ hTERT+)
Interaction
Interacts with EPHA4; effector of EPHA4 in axon guidance linking EPHA4 activation to RAC1 regulation.
Molecular function
GTPase activation
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