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CHRNE
Anti-CHRNE Recombinant Antibody Products
- anti-CHRNE immunotoxin (Fab)-PE (AGTO-L054E)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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For Research Use Only. Not For Clinical Use.
Acetylcholine receptors at mature mammalian neuromuscular junctions are pentameric protein complexes composed of four subunits in the ratio of two alpha subunits to one beta, one epsilon, and one delta subunit. The acetylcholine receptor changes subunit composition shortly after birth when the epsilon subunit replaces the gamma subunit seen in embryonic receptors. Mutations in the epsilon subunit are associated with congenital myasthenic syndrome.
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enriched (Late spermatids)
Immune cell specificity
Immune cell enhanced (gdT-cell)
Cell line specificity
Group enriched (HEL, HMC-1)
Interaction
Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains. The muscle heteropentamer composed of alpha-1, beta-1, delta, epsilon subunits interacts with the alpha-conotoxin ImII (PubMed:15609996).
Molecular function
Ion channel, Ligand-gated ion channel, Receptor
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