Anti-CIB2 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is a leader in sensory neuroscience research, providing premium anti-CIB2 recombinant antibodies. CIB2, short for Calcium and Integrin Binding Family Member 2, is a calcium-binding protein necessary for the sense of hearing and balance. Our top-tier antibodies against CIB2 are critical to research into hereditary deafness as this protein is essential for hair cell function in the inner ear and is mutated in some cases of Usher syndrome and other sensorineural hearing loss.

CIB2: An Essential Calcium-Binding Protein for Hearing

Calcium and integrin binding family member 2 (CIB2) belongs to a family of EF-hand calcium-binding proteins. It is abundantly expressed in the stereocilia of sensory hair cells of the inner ear and in retinal photoreceptors. CIB2 is a constituent of the mechano-electrical transduction (MET) complex in the hair cells of the inner ear. The MET complex is the protein machinery that translates sound vibrations into a neural signal. CIB2 likely acts as a calcium sensor or buffer in the MET complex, playing a role in adaptation and sensitivity regulation. Mutations in this gene are known to cause non-syndromic deafness (DFNB48) and a type of Usher syndrome (USH1J). Usher syndrome is a tragic disorder leading to deafness and progressive blindness.

Alternative Names

KIP2; USH1J; DFNB48

Background

The protein encoded by this gene is homologous to KIP/CIB, calcineurin B, and calmodulin. The gene product is a calcium-binding regulatory protein, which binds to DNA-dependent protein kinase catalytic subunits (DNA-PKcs), with a role in photoreceptor cell maintenance. Mutations in this gene cause deafness, autosomal recessive, 48 (DFNB48), and also Usher syndrome 1J (USH1J). Alternative splicing results in multiple transcript variants.

Anti-CIB2 rAb Products

Our anti-CIB2 recombinant antibodies are designed for maximum specificity and performance. Produced with the highest quality standards and extensively validated for accurate CIB2 protein detection in inner ear and retinal tissue, they are optimized for immunofluorescence studies to determine its localization within stereocilia and also for Western Blot. This rAb gives the reliable and precise performance you expect and need from Creative Biolabs for state-of-the-art sensory research.

Table 1. Featured anti-CIB2 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

At Creative Biolabs, we are committed to advancing the specialized field of hearing research, and for that, our scientists leverage the latest in antibody production platforms. Our anti-CIB2 recombinant antibodies are expressed in highly optimized systems that ensure they are able to recognize the native protein, so you can be confident in the specificity and activity of the antibodies for your experiment.

Featured Anti-CIB2 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CIB2 recombinant antibody production.

Fig.2 Gram-scale anti-CIB2 recombinant antibody production.

rAb Modalities

Creative Biolabs is dedicated to enabling scientific discovery by providing flexible antibody solutions. We offer our anti-CIB2 recombinant antibodies in a variety of customizable formats to meet the needs of a wide range of experimental requirements so that researchers worldwide can better understand the molecular cause of deafness.

Fig.3 Full-length anti-CIB2 recombinant antibody production and modalities.

Unlock the important functions of CIB2 in the inner ear with Creative Biolabs recombinant antibodies. Our portfolio is characterized by its unmatched specificity and extensive validation, so you can be confident you have the right tools for your research into hereditary hearing loss. Choose Creative for quality that powers discovery. Contact one of our specialists today.