Disease related genes, Human disease related genes, Potential drug targets, Transporters, Voltage-gated ion channels
Intracellular, Membrane (different isoforms)
Cell type enriched (Rod photoreceptor cells)
Not detected in immune cells
Cell line enhanced (CAPAN-2, RT4, U-2 OS)
Forms a heterotetramer with CNGB1 in a 3:1 ratio. May also form cyclic nucleotide-activated homotetrameric channels, that are efficiently activated by saturating cGMP, but poorly activated by saturating cAMP compared to the heterotetramer with CNGB1.
Ion channel, Ligand-gated ion channel
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For Research Use Only. Not For Clinical Use.