Anti-CNGA1 Products

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For Research Use Only. Not For Clinical Use.

The team at Creative Biolabs is passionate about bringing ground-breaking discoveries in sensory neuroscience to life. We are excited to offer top-notch anti-CNGA1 recombinant antibodies for your research needs. As the pore-forming alpha subunit of the principal cation channel of the rod photoreceptor, CNGA1 is a major target for probing the molecular etiology of retinitis pigmentosa and studying the fundamental process of phototransduction.

CNGA1: The Photoreceptor Cation Channel

Cyclic Nucleotide Gated Channel Alpha 1 (CNGA1) is the pore-forming alpha subunit of the cGMP-gated cation channel in the plasma membrane of rod photoreceptor outer segments. The channel is the ultimate effector of the phototransduction cascade. In darkness, elevated levels of cGMP noncompetitively bind to and open the channel, allowing an inward “dark current”. Photons absorbed by the rhodopsin pigment cause a precipitous drop in cGMP levels, closing the channel and hyperpolarizing the cell, thereby propagating the light signal. Loss-of-function mutations in CNGA1 cause autosomal recessive retinitis pigmentosa (RP), a blinding degenerative disease.

Alternative Names

CNGA1; cyclic nucleotide gated channel alpha 1; CNCG; CNG1; RP49; CNCG1; CNG-1; RCNC1; RCNCa; RCNCalpha; cGMP-gated cation channel alpha-1; CNG channel alpha-1; interleukin-1 homologue; cyclic nucleotide-gated channel alpha-1; cyclic nucleotide-gated cation channel 1; cyclic nucleotide-gated channel, photoreceptor; rod photoreceptor cGMP-gated channel subunit alpha;

Background

The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene.

Anti-CNGA1 rAb Products

Creative Biolabs anti-CNGA1 recombinant antibodies are designed to perform. Through careful validation, our rAbs are highly specific and reliable for the accurate detection of the CNGA1 subunit. We have optimized this antibody for various applications such as IHC and immunofluorescence to elucidate its precise localization in the rod outer segment or Western Blot to analyze its role in the complex protein machinery of the retina. Our rAbs are the dependable tool you need for your retinal research.

Table 1. Featured anti-CNGA1 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs supports your work in the highly specialized area of vision research by using the latest technologies for antibody production. Our anti-CNGA1 recombinant antibodies are expressed in carefully optimized systems, so they can precisely recognize the native channel subunit. This gives you a tool you can trust for highly specific and active applications.

Featured Anti-CNGA1 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CNGA1 recombinant antibody production.

Fig.2 Gram-scale anti-CNGA1 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to advancing your research with high quality, flexible antibody solutions. Our anti-CNGA1 recombinant antibodies are available in multiple modalities to provide the flexibility you need for all your experimental applications. Probe this important ion channel and drive discovery in your lab with antibodies from Creative Biolabs.

Fig.3 Full-length anti-CNGA1 recombinant antibody production and modalities.

Let Creative Biolabs take your vision research to the next level with premium anti-CNGA1 recombinant antibodies. Our library offers extensive validation and the specificity you need to study this important protein in RP. You can count on our expertise to give you the tools you need to support your research. Speak to one of our experts today.