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CNKSR1

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For Research Use Only. Not For Clinical Use.


Background

This gene encodes a protein containing several motifs involved in protein protein interaction, including PDZ, PH (Pleckstrin homology), and SAM (sterile alpha motif) domains. The encoded protein acts as a scaffold component for receptor tyrosine kinase signaling and may mediate crosstalk between different signaling pathways. Alternative splicing results in multiple transcript variants.
Protein class

Cancer-related genes

Predicted location

Intracellular

Single cell type specificity

Low cell type specificity

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (A-431, BEWO, CAPAN-2, HaCaT, hTCEpi, OE19, SK-BR-3, T-47d)

Interaction

Interacts with RHO and RALGDS.

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