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COLQ
This gene encodes the subunit of a collagen-like molecule associated with acetylcholinesterase in skeletal muscle. Each molecule is composed of three identical subunits. Each subunit contains a proline-rich attachment domain (PRAD) that binds an acetylcholinesterase tetramer to anchor the catalytic subunit of the enzyme to the basal lamina. Mutations in this gene are associated with endplate acetylcholinesterase deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Inhibitory neurons, Excitatory neurons, Oligodendrocytes, Oligodendrocyte precursor cells, Astrocytes, Late spermatids, NK-cells)
Immune cell specificity
Immune cell enriched (MAIT T-cell)
Cell line specificity
Group enriched (BEWO, HDLM-2, U-937)
Interaction
Homotrimer. Component of the asymmetric form of AChE, a disulfide-bonded oligomer composed of the collagenic subunits (Q) and a variable number of asymmetric catalytic subunits (T). The N-terminal of a collagenic subunit (Q) associates with the C-terminal of a catalytic subunit (T).
More Types Infomation
- Recombinant Human Anti-human COLQ Antibody scFv Fragment (MHH-229-S(P))
-
- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: WB, Neut, FuncS
-
- Derivation: Human
- Species Reactivity: Human
- Type: IgG
- Application: Neut, WB, FuncS
- Recombinant Human Anti-human COLQ Antibody Fab Fragment (MHH-229-F(E))
-
- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: IP, IF, Biosensors, FuncS
- Recombinant Anti-human COLQ Antibody scFv Fragment (MOB-229-S(P))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, IF, FuncS
- Recombinant Anti-human COLQ Antibody Fab Fragment (MOB-229-F(E))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: Neut, WB, FuncS
- Recombinant Anti-human COLQ Antibody (MOB-229)
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: WB, Dot, FuncS
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For Research Use Only. Not For Clinical Use.