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CORT
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For Research Use Only. Not For Clinical Use.
Precortistatin is a protein that in humans is encoded by the CORT gene. The 105 amino acid residue human precortistatin in turn is cleaved into cortistatin-17 and cortistatin-29. Cortistatin-17 is the only active peptide derived from the precursor. It binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs. Unlike somatostatin, when infused into the brain, it enhances slow-wave sleep. It binds to sites in the cortex, hippocampus and the amygdala.
Predicted location
Secreted
Single cell type specificity
Cell type enhanced (Late spermatids, Early spermatids, Adipocytes, Spermatocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (PC-3)
Molecular function
Hormone
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