Anti-COX7B Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
Creative Biolabs is your trusted source for mitochondrial biology and top-grade anti-COX7B recombinant antibodies. COX7B is a small, membrane-spanning subunit of Complex IV (Cytochrome c Oxidase), a fundamental enzyme in the electron transport chain that requires a fine-tuned stoichiometry for optimal activity. Creative's high-quality anti-COX7B recombinant antibodies are a crucial tool for studying mitochondrial integrity and the native architecture of respiratory supercomplexes.
COX7B: A Small Transmembrane Subunit of Complex IV
Cytochrome c Oxidase Subunit 7B (COX7B) is a nuclear-encoded subunit of Complex IV. COX7B is one of the small, peripheral subunits that tether the catalytic core to the inner mitochondrial membrane. Despite their small size, these subunits are essential for the efficient assembly of the complex and for their stability in the supercomplexes of the respiratory chain. The study of COX7B is relevant for a deeper understanding of the complex stoichiometry and assembly process that regulate mitochondrial energy production.
Alternative Names
Cytochrome C Oxidase Subunit VIIb; Cytochrome C Oxidase Polypeptide VIIb; Cytochrome-C Oxidase Chain VIIb; LSDMCA2; APLCC
Background
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIb, which is highly similar to bovine COX VIIb protein and is found in all tissues. This gene may have several pseudogenes on chromosomes 1, 2, 20 and 22.
Protein class
Disease related genes, Human disease related genes, Metabolic proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Distal tubular cells, Cardiomyocytes, Proximal tubular cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I1 (or COX4I2), COX5A, COX5B, COX6A1 (or COX6A2), COX6B1 (or COX6B2), COX6C, COX7A2 (or COX7A1), COX7B, COX7C, COX8A and NDUFA4, which are encoded in the nuclear genome (PubMed:30030519). The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (PubMed:28844695).
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Anti-COX7B rAb Products
Creative Biolabs' anti-COX7B recombinant antibodies are designed with precision and engineered for optimal performance and specificity. They are carefully validated to specifically detect the COX7B protein in mitochondrial fractions. Optimized for applications such as Western Blot and Blue Native PAGE, our recombinant antibodies (rAbs) offer the reliability and accuracy you need for in-depth metabolic research.
Table 1. Featured anti-COX7B recombinant antibody products at Creative Biolabs.
| Cat. No. | Product Name | Target Species | Host Species | Applications |
| MOR-0774 | Hi-Affi™ Rabbit Anti-COX7B Recombinant Antibody (clone DS774AB) | Human | Rabbit IgG | WB, IHC, ICC |
Customer Reviews
Excellent
Jen**aHi-Affi™ Rabbit Anti-COX7B Recombinant Antibody (clone DS774AB)
The anti-COX7B antibody from Creative Biolabs was perfect for our study. We could easily detect it by Western blot on mitochondrial fractions. The expression was also clearly stable in our cell lines.
23/Apr/2024
rAb Production
Creative Biolabs' advanced antibody production platforms are purpose-built to support the highly-specialized field of mitochondrial biology. The anti-COX7B recombinant antibodies are expressed in a system optimized for the correct recognition of the native protein, providing you with a specific and active tool.
Featured Anti-COX7B Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-COX7B recombinant antibody production.
Fig.2 Gram-scale anti-COX7B recombinant antibody production.
rAb Modalities
Creative Biolabs is committed to accelerating scientific discovery by providing a wide range of flexible antibody modalities. Our anti-COX7B recombinant antibodies are available in multiple customizable formats to meet the unique needs of your research.
Fig.3 Full-length anti-COX7B recombinant antibody production and modalities.
Unlock the secrets of Complex IV assembly with the superior performance of Creative Biolabs' top-grade anti-COX7B recombinant antibodies. Creative's portfolio of rigorously validated and consistent products will give your work a solid foundation. Contact our experts today.