Anti-CPB2 Products

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For Research Use Only. Not For Clinical Use.

We, at Creative Biolabs, are a global leader in the field of hematology and thrombosis research, providing you with elite anti-CPB2 recombinant antibodies. The enzyme Carboxypeptidase B2 (CPB2), also known as TAFI, is a vital bridge between the coagulation and fibrinolytic systems and has been identified as a major drug target to prevent thrombosis. Our high-quality anti-CPB2 antibodies are important tools for understanding its critical role in determining clot stability as well as for developing next-generation anti-thrombotic and anti-fibrinolytic drugs.

CPB2: The Thrombin-Activatable Fibrinolysis Inhibitor

CPB2 is a plasma zymogen and more commonly known as the Thrombin-Activatable Fibrinolysis Inhibitor (TAFI). It is produced in the liver and secreted in an inactive form in the plasma. In blood coagulation, CPB2 is activated by the thrombin-thrombomodulin complex. The active enzyme (TAFIa) downregulates fibrinolysis (breakdown of blood clot) by removing the C-terminal lysine and arginine residues from the partially degraded fibrin, eliminating the binding sites for plasminogen, thereby preventing the clot from getting lysed. The increased level or activity of TAFI is a risk factor for thrombotic diseases such as deep vein thrombosis and myocardial infarction.

Alternative Names

CPB2; carboxypeptidase B2; CPU; PCPB; TAFI

Background

Carboxypeptidases hydrolyze C-terminal peptide bonds. They are subclassified into metallo-, serine, and cysteine carboxypeptidases based on their catalytic mechanisms. They are further named based on their substrate specificity as carboxypeptidase A (aliphatic residues) or carboxypeptidase B (basic amino residues). The protein encoded by this gene is activated by trypsin and is specific for carboxypeptidase B substrates. The mature protein resulting from thrombin activation downregulates fibrinolysis. Polymorphisms have been described for this gene and for the promoter region. Alternate splicing generates multiple transcript variants.

Anti-CPB2 rAb Products

Our anti-CPB2 recombinant antibodies have been engineered to have high affinity and specificity. Our products have been thoroughly validated to ensure that they will accurately detect TAFI in your plasma and other biological fluids. Optimized for all your critical applications including ELISA for quantification and functional assays to block its activation or activity, these rAbs will give you the reliability you need for cutting-edge hematology research and drug development.

Table 1. Featured anti-CPB2 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

At Creative Biolabs, we are focused on enabling rapid progress in the field of hematology. We leverage our advanced production technologies to ensure that our anti-CPB2 recombinant antibodies are expressed in optimized mammalian cell lines for proper folding and activity, which is critical for the development of functional inhibitors.

Featured Anti-CPB2 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CPB2 recombinant antibody production.

Fig.2 Gram-scale anti-CPB2 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to providing our research community with flexible and innovative tools. Our anti-CPB2 recombinant antibodies are available in several customizable modalities to best meet your project's needs. We offer full-length IgGs for in vivo blocking studies and Fab fragments for structural biology applications.

Fig.3 Full-length anti-CPB2 recombinant antibody production and modalities.

CPB2-Targeted Drug Information

Table 2. Public drug targeting CPB2.

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

Accelerate your thrombosis research with Creative Biolabs' superior anti-CPB2 (TAFI) recombinant antibodies. Our portfolio is defined by its high specificity and rigorous validation standards, providing the ideal tools for both fundamental research and therapeutic development. Trust our expertise to support your important work. Contact our specialists today.