CPEB

Cytoplasmic polyadenylation element binding protein, is a highly conserved RNA-binding protein that promotes the elongation of the polyadenine tail of messenger RNA. CPEB most commonly activates the target RNA for translation, but can also act as a repressor, dependent on its phosphorylation state. In animals, CPEB is expressed in several alternative splicing isoforms that are specific to particular tissues and functions, including the self-cleaving Mammalian CPEB3 ribozyme. CPEB was first identified in Xenopus oocytes and associated with meiosis; a role has also been identified in the spermatogenesis of Caenorhabditis elegans.In immature zebrafish oocytes, The translational activation of maternal mRNAs, including cyclin B1 mRNA, is triggered by cytoplasmic polyadenylation, which is mainly regulated by CPEB that resides in the 30 untranslated region (UTR).